The Prostate Cancer Prevention Trial and European Randomized Study of Screening for Prostate Cancer risk calculators indicating a positive prostate biopsy: a comparison

BJU International
Roderick C N van den BerghFritz H Schröder

Abstract

To assess the potential problem that different tools for predicting a positive outcome of prostate biopsy can produce divergent outcomes in the same man, by comparing the risk calculators based on the Prostate Cancer Prevention Trial (PCPT) and the European Randomized Study of Screening for Prostate Cancer (ERSPC). In the prostate-specific antigen (PSA) range of 0.2-30.0 ng/mL, the prediction curves of 'virtual' standard study participants were evaluated using both prediction tools. The effects of prostate volume, digital rectal examination, transrectal ultrasonography (TRUS), previous negative biopsy, family history, race, and age were also assessed. Important differences in underlying study design and populations between the PCPT and ERSPC cause an essential discrepancy between the risk calculators. In the PCPT there were few biopsies in the higher PSA ranges, and in the ERSPC in the lower PSA ranges. Both risk indicators have incorporated some variables that are not used in the other, because they were insignificant in multivariate analysis. TRUS and especially prostate volume (not available in the PCPT) have a considerably larger effect on predictions in comparable PSA ranges than race, age, family history of prostate cance...Continue Reading

References

Jun 1, 1995·Controlled Clinical Trials·P FeiglL G Ford
Feb 1, 2003·Urology·Jay B BasilloteJohn A Fracchia
Jul 25, 2003·The New England Journal of Medicine·Fritz H Schröder, Ries Kranse
Oct 22, 2003·The Journal of Urology·Patrick C Walsh
Feb 27, 2004·BJU International·F H SchröderUNKNOWN ERSPC
Apr 12, 2005·The Journal of Urology·Saadettin Yilmaz EskicorapciHaluk Ozen
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Aug 29, 2006·European Urology·Felix K-H ChunMarkus Graefen
Sep 27, 2007·Journal of the National Cancer Institute·Gabriel P HaasGustavo de la Roza
Aug 21, 2008·The Prostate·Ries KranseFritz H Schröder

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Citations

Apr 13, 2010·Nature Reviews. Urology·Stacy Loeb, William J Catalona
Aug 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew J VickersHans Lilja
Oct 29, 2011·Critical Reviews in Oncology/hematology·Chris H Bangma, Monique J Roobol
Sep 8, 2009·European Urology·Monique J RoobolFritz H Schröder
Nov 15, 2011·BJU International·Hashim U AhmedUNKNOWN Transatlantic Consensus Group on Active Surveillance and Focal Therapy for Prostate Cancer (appendix)
Oct 5, 2010·BJU International·Mário OliveiraAmérico Santos
Mar 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heidi A van VugtMonique J Roobol
Aug 16, 2011·Urology·Prasanna SooriakumaranAshutosh Tewari
Dec 3, 2013·Therapeutic Advances in Urology·K Clint Cary, Mathew R Cooperberg
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Dragan IlicPhilipp Dahm
Jul 6, 2020·BMC Medical Informatics and Decision Making·Amirhossein JalaliR William Watson

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