Abstract
The embryological origin of the utricle is thought to be a remnant of the fused caudal ends of the müllerian ducts (MDs). Others propose that the urogenital sinus (UGS) contributes either partially or totally to the development of this structure. Using immunohistochemical probes, we provide strong evidence that the utricle is of UGS origin only. Human fetal prostates, gestational ages 9 to 24 weeks, were serially cross-sectioned. Representative sections were stained with antibodies to p63 (basal cell marker), vimentin (mesoderm marker), uroplakins (marker for urothelium) Pax-2 (expressed in ductal and mesenchyme of urogenital system including the MDs and wolffian ducts) and Ki67 (proliferation). Apoptosis was detected with the TUNEL assay. By 9 weeks there was weak expression of p63 in the basal layer of the UGS. At 11 weeks there was increased staining of p63 in the UGS and some p63 staining of the fused MDs, which expressed Pax-2 at this time. At 14 to 15 weeks as the MDs were undergoing apoptosis, there was an ingrowth of uroplakin-expressing UGS epithelium into the periurethral stroma, which formed a plate of p63 positive cells just beneath the UGS that was Ki67 positive. The remaining caudal MD epithelium was p63 negative ...Continue Reading
References
Jan 1, 1990·The Prostate·N WernertG Dhom
Jan 1, 1974·Urologia Internationalis·L H Zondek, T Zondek
Dec 1, 1984·Developmental Biology·O TaguchiS J Robboy
Aug 25, 2000·The Journal of Urology·E ShapiroX R Wu
Dec 18, 2001·The Journal of Urology·A GanesanA Steinberg
Dec 12, 2002·Urology·Temuçin SenkulC neyt Adayener
Mar 1, 1960·Fertility and Sterility·M M GRUMBACH, J R DUCHARME
Sep 23, 2003·The Journal of Urology·Selcuk YucelLaurence S Baskin
Dec 3, 2003·Differentiation; Research in Biological Diversity·Gen YamadaGerald R Cunha
Citations
Jun 28, 2006·Abdominal Imaging·D A Torigian, P Ramchandani
Feb 3, 2009·Pediatric Surgery International·Fumi MatsumotoTakashi Obara
Apr 9, 2008·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·H OstrerE Shapiro
Nov 1, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elisabeth J PechrigglHelga Fritsch
Aug 19, 2014·Case Reports in Radiology·Dustin JohnsonWinnie Mar
Feb 24, 2016·Organogenesis·Zograb Makiyan
Feb 15, 2013·Journal of Anatomy·Helga FritschOlaf Reich
Nov 22, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Vincenzo Puppo
Oct 12, 2005·The Journal of Urology·Ellen ShapiroXue-Ru Wu
Sep 24, 2011·ISRN Obstetrics and Gynecology·Vincenzo Puppo
Sep 17, 2013·The Prostate·Camelia M SaffariniKim Boekelheide
Jul 23, 2013·Anatomy & Cell Biology·Yukio KatoriTetsuaki Kawase
Jan 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Luke E HofkampBarry G Timms
Dec 18, 2009·The Prostate·Qian ChenRobert A Sikes
Oct 12, 2013·American Journal of Medical Genetics. Part a·Diana D VillarrealGeorge C Powers
Mar 7, 2020·Science Translational Medicine·Mitchell G LawrenceGail P Risbridger
Aug 21, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Seiji FuruyaShogo Shimamura
Oct 3, 2018·Journal of the American Animal Hospital Association·Jennifer McGillAudrey Cook
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jitu W GeorgeJose M Teixeira
Sep 23, 2020·The American Journal of Surgical Pathology·Daniel GrosserJonathan I Epstein
Jul 10, 2021·Case Reports in Pediatrics·Rashida ShakirZarine R Balsara
Aug 4, 2021·Biology Open·Jaya Kumari, Pradip Sinha
May 9, 2008·Differentiation; Research in Biological Diversity·Colin C Pritchard, Peter S Nelson