PMID: 7538441May 1, 1995Paper

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

Immunity
M A ReadT Collins

Abstract

Multiple cell adhesion proteins are up-regulated in vascular endothelial cells in response to TNF alpha and other inflammatory cytokines. This increase in cell adhesion gene expression is thought to require the transcription factor NF-kappa B. Here, we show that peptide aldehyde inhibitors of the proteasome, a multicatalytic protease recently shown to be required for the activation of NF-kappa B, block TNF alpha induction of the leukocyte adhesion molecules E-selectin, VCAM-1, and ICAM-1. Striking functional consequences of this inhibition were observed in analyses of leukocyte-endothelial interactions under defined flow conditions. Lymphocyte attachment to TNF alpha-treated endothelial monolayers was totally blocked, while neutrophil attachment was partially reduced but transmigration was essentially prevented.

References

Dec 1, 1992·The Journal of Experimental Medicine·A S NeishT Collins
Jun 4, 1992·Nature·A L Goldberg, K L Rock
Feb 11, 1992·The American Journal of Physiology·J ShenM A Gimbrone
Apr 2, 1992·Nature·R MarmorsteinS C Harrison
Apr 1, 1990·Physiological Reviews·J S Pober, R S Cotran
Sep 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·M I CybulskyT Collins
Dec 1, 1993·The Journal of Clinical Investigation·O AbbassiC W Smith
Feb 1, 1994·The Journal of Experimental Medicine·M A ReadT Collins
Oct 1, 1994·Molecular and Cellular Biology·M Z WhitleyT Collins
Feb 23, 1995·The American Journal of Cardiology·M A Gimbrone
Aug 1, 1993·Seminars in Immunology·S D Rosen
Feb 24, 1995·Cell·D Thanos, T Maniatis
Oct 7, 1994·Cell·A Ciechanover
Sep 1, 1994·Trends in Biochemical Sciences·J M Peters
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·T S FincoA S Baldwin
Jul 1, 1993·Genes & Development·M L ScottD Baltimore
Aug 1, 1993·The Journal of Experimental Medicine·W A MullerD M Phillips
Oct 1, 1993·Molecular and Cellular Biology·C Kunsch, C A Rosen
Jan 1, 1993·International Review of Cytology·M GrilliM J Lenardo
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K BrownU Siebenlist

❮ Previous
Next ❯

Citations

Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·T IkebeK Shirasuna
Jan 1, 1997·Biopolymers·M BogyoH L Ploegh
Apr 29, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antje LudwigKarl Stangl
Sep 28, 2010·Angiogenesis·Shoshana GreenbergerJoyce Bischoff
Jun 14, 2006·Cancer Metastasis Reviews·Jocelyn HolashMichael S Gordon
Mar 10, 2010·Journal of Neuro-oncology·Surasak PhuphanichJeffrey J Olson
May 2, 2009·Archives of Pharmacal Research·Dinesh ThapaJung-Ae Kim
Aug 1, 1996·Immunology Today·F H BachS C Robson
Aug 1, 1996·Cytokine & Growth Factor Reviews·P Beauparlant, J Hiscott
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·C A Foster
Aug 11, 2001·Journal of Neuroimmunology·H HosseiniV Lotteau
May 10, 2003·Cancer Treatment Reviews·William S Dalton
May 10, 2003·Cancer Treatment Reviews·Paul Richardson
May 10, 2003·Cancer Treatment Reviews·Heinz Josef Lenz
Jun 1, 1996·Current Opinion in Cell Biology·H L Pahl, P A Baeuerle
Jun 26, 2003·Bioorganic & Medicinal Chemistry Letters·Alfredo C CastroJulian Adams
Apr 1, 1998·Trends in Cardiovascular Medicine·G C Parry, N Mackman
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·Géraldine CarrardBertrand Friguet
Feb 14, 1998·Nature Genetics·A D D'Andrea, C N Serhan
Apr 3, 1999·British Journal of Pharmacology·J PanésD N Granger
Sep 19, 2002·British Journal of Clinical Pharmacology·I M ShahP J Elliott
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M GriscavageL J Ignarro
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·L MengC M Crews
Jun 20, 2012·International Journal of Rheumatic Diseases·Selvarajan ChitraGopalakrishnan Rajasekhar
Apr 18, 2012·Infection and Immunity·Toshinori KomatsuKenji Matsushita
Mar 9, 2002·Journal of Virology·Michael D RobekFrancis V Chisari
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Dharminder ChauhanKenneth C Anderson
Jul 3, 2004·American Journal of Respiratory Cell and Molecular Biology·Raj WadgaonkarJoe G N Garcia

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved