PMID: 18202793Jan 19, 2008Paper

The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer

Oncology Reports
Xiao-Tong HuChao He

Abstract

The proteasome subunit PSMA7 located on the 20q13 amplicon was found to be differentially expressed in colorectal cancer by semiquantitative RT-PCR. PSMA7 mRNA was overexpressed in 37.5% (12/32) colorectal cancer tissues while it was either of a low level or not expressed in matched normal mucosa. The aim of this study was to examine the PSMA7 protein expression in 62 colorectal cancer primary sites, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlations of this expression with the clinicopathological parameters. PSMA7 high expression was detected in 38.8% (24/62) colorectal cancer primary sites, 52.9% (18/34) lymph node metastatic sites and 100% (13/13) liver metastatic sites but not in the normal colorectal tissues. The PSMA7 high expression was significantly correlated with liver metastasis (P=0.028). Survival was significantly lower in patients with a PSMA7 high expression than in those with a PSMA7 low expression (P=0.0012). Moreover, in multivariate analysis, the PSMA7 expression demonstrated an independent prognostic factor (P=0.004, relative risk 5.057; 95% confidence interval, 1.682-15.201). These results indicated that PSMA7 may play an important role in color...Continue Reading

Citations

Mar 19, 2013·Journal of Proteomics·Ioannis P TrougakosVassilis G Gorgoulis
May 14, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·William K K WuJoseph J Y Sung
Mar 22, 2016·Cell Reports·Achuth PadmanabhanMark Hochstrasser
Nov 7, 2009·The American Journal of Pathology·Tammy L RomanuikMarianne D Sadar
Aug 23, 2012·PloS One·María González-GonzálezJosé María Sayagués
Oct 12, 2010·Acta Biochimica Et Biophysica Sinica·Chao ZhangJun Wan

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