The protection of primates against soman poisoning by pretreatment with pyridostigmine
The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.
The use of carbamates and atropine in the protection of animals against poisoning by 1,2,2-trimethylpropyl methylphosphonofluoridate
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION
Effectiveness of 1,2,3,4-tetrahydro-9-aminoacridine (THA) as a pretreatment drug for protection of mice from acute diisopropylfluorophosphate (DFP) intoxication
Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure
The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes
Differential sensitivity of CNS regions to acetylcholinesterase inhibition following chronic low-dose soman treatment in the rat
Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization
A swimming test for assessing effects of drugs upon motor performance in the guinea-pig (Cavia porcellus)
Effects of subacute administration of physostigmine on blood acetylcholinesterase activity, motor performance, and soman intoxication
Behavioral toxicity of anticholinesterases in primates: chronic pyridostigmine and soman interactions
Cholinolytic antagonism to the disruptive effects of oral low doses of pyridostigmine on simple discrimination performance in rats
Acute effects of oral low doses of pyridostigmine on simple visual discrimination and unconditioned consummatory acts in rats
Effects of anticholinergic-antiparkinsonian drugs on striatal neurotransmitter levels of rats intoxicated with soman
Pyridostigmine-induced inhibition of blood acetylcholinesterase (AChE) and resulting effects on manual ocular tracking performance in the trained baboon
Effect of acute physostigmine-hyoscine pretreatment on the neurochemical changes produced by soman in the guinea-pig
The effects of pyridostigmine bromide and permethrin, alone or in combination, on response acquisition in male and female rats
The combined effects of pyridostigmine and chronic stress on brain cortical and blood acetylcholinesterase, corticosterone, prolactin and alternation performance in rats
Subchronic physostigmine pretreatment in guinea pigs: effective against soman and without side effects
The effects of acute and repeated pyridostigmine bromide administration on response acquisition with immediate and delayed reinforcement
Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment
Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig
Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries
Effectiveness of procyclidine in combination with carbamate prophylactics against diisopropylfluorophosphate poisoning
Continuous administration of low dose rates of physostigmine and hyoscine to guinea-pigs prevents the toxicity and reduces the incapacitation produced by soman poisoning
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine
Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (±)-Anatoxin A poisoning in rats
Effect of pretreatment with CBDP on the toxicokinetics of soman stereoisomers in rats and guinea pigs
An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents
Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity
Pharmacological antagonism of lethal effects induced by O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate
Effects of subacute pretreatment with carbamate together with acute adjunct pretreatment against nerve agent exposure
Use of the accelerating rotarod for assessment of motor performance decrement induced by potential anticonvulsant compounds in nerve agent poisoning
Efficacy of injectable anticholinergic drugs against soman-induced convulsive/subconvulsive activity
Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity
Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys
Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
Determination of anti-convulsant and life-preserving capacities of three types of auto-injector therapies against soman intoxication in rats
A comparison of the decarbamoylation rates of physostigmine-inhibited plasma and red cell cholinesterases of man with other species
Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity
Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs
Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms
Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatment
Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds
Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure
An ex vivo approach for the evaluation of reversible inhibitors as potential pretreatments against organophosphate toxicity
Prophylaxis with human serum butyrylcholinesterase protects Göttingen minipigs exposed to a lethal high-dose of sarin vapor
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase
Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat
Pretreatment and prophylaxis against nerve agent poisoning: Are undesirable behavioral side effects unavoidable?
Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus)
A theoretical kinetic analysis of the protective action exerted by eserine and other carbamate anticholinesterases against poisoning by organophosphorus compounds
Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning
Cardiorespiratory effects following acute exposure to pyridostigmine bromide and/or N,N-diethyl-m-toluamide (DEET) in rats
Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response
Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon
Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys
Investigation of evolved paraoxonase-1 variants for prevention of organophosphorous pesticide compound intoxication
Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes
In-vitro and in-vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates
Retention of soman in rats, guinea-pigs and marmosets: species-dependent effects of the soman simulator, pinacolyl dimethylphosphinate (PDP)
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