PMID: 37298May 1, 1979

The protection of primates against soman poisoning by pretreatment with pyridostigmine

The Journal of Pharmacy and Pharmacology
P DirnhuberJ A Stratton


The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.


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