The protection role of heat shock protein 70 (HSP-70) in the testes of cadmium-exposed rats.

Bioinformation
Manar E SelimMaha H Daghestani

Abstract

Cadmium (Cd) is an environmental carcinogenic pollutant known to inactivate several proteins involved in DNA repair systems while at the same time creating an oxidative stress that can result in additional DNA lesions. The testis and the lung are the target organs for cadmium carcinogenesis. Increased production of oxidants in vivo can cause damage to intracellular macromolecules such as DNA, proteins and lipids, which in turn lead to oxidative injury. So, this investigation aimed to evaluate the protective role of L-Carnitine through up regulation of HSPs against DNA damage induced by cadmium chloride. The current study was carried out on forty adult male rats, each with average weight 220-250g., were divided into 4 equal groups. 1(st) group was received saline solution (0.5 ml/100 g body weight) and kept as control. 2(nd) group was received 500mg / kg body weight L-Carnitine intraperitoneally (IP). 3(rd) group was administered 1.2 mg cadmium chloride IP. 4(th) group was received both cadmium chloride and L-Carnitine simultaneously. The comet assay parameters showed significantly increased HSP70 and DNA damage in testis cells after 10 and 56 days in the third group. Meanwhile, HSP70 showed significantly decreased levels after ...Continue Reading

Citations

Feb 6, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Young-Mi GoDean P Jones
Jul 22, 2014·Proteomics·Yan ZhangQingyou Xia
Apr 24, 2014·Journal of Toxicology and Environmental Health. Part a·Anette K KrogenæsPaul A Fowler
Apr 21, 2017·Environmental Science and Pollution Research International·He HuangXiaohua Teng
Nov 28, 2020·Andrologia·Supataechasit YannasithinonSitthichai Iamsaard
Apr 10, 2021·Environmental Science and Pollution Research International·Mohammad Ehsan Taghavizadeh YazdiSeyed Hadi Mousavi

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Methods Mentioned

BETA
ELISA
electrophoresis
Enzyme-linked immunosorbent assay
chromosomal aberrations

Software Mentioned

Comet

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