The protective and therapeutic function of small heat shock proteins in neurological diseases.

Frontiers in Immunology
Sara BrownellLawrence Steinman

Abstract

Historically, small heat shock proteins (sHSPs) have been extensively studied in the context of being intracellular molecular chaperones. However, recent studies looking at the role of sHSPs in neurological diseases have demonstrated a near universal upregulation of certain sHSPs in damaged and diseased brains. Initially, it was thought that sHSPs are pathological in these disease states because they are found in the areas of damage. However, transgenic overexpression and exogenous administration of sHSPs in various experimental disease paradigms have shown just the contrary - that sHSPs are protective, not pathological. This review examines sHSPs in neurological diseases and highlights the potential for using these neuroprotective sHSPs as novel therapeutics. It first addresses the endogenous expression of sHSPs in a variety of neurological disorders. Although many studies have examined the expression of sHSPs in neurological diseases, there are no review articles summarizing these data. Furthermore, it focuses on recent studies that have investigated the therapeutic potential of sHSPs for neurological diseases. Finally, it will explain what we think is the function of endogenous sHSPs in neurological diseases.

Citations

Jan 22, 2013·Cell Stress & Chaperones·Gabriella GrudenGraziella Bruno
May 27, 2014·Molecular and Cellular Neurosciences·Ryan T CameronGeorge S Baillie
Mar 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·María M Leal-LasarteCintia Roodveldt
Apr 18, 2016·Cellular and Molecular Life Sciences : CMLS·Britta Bartelt-KirbachNikola Golenhofen
Oct 18, 2019·Frontiers in Pharmacology·Jack M WebsterLaura J Blair
Apr 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina KotelnikovaPablo Villoslada
Sep 25, 2019·Experimental Eye Research·Sumaya HamadmadColleen M Cebulla
Feb 26, 2021·Archives of Biochemistry and Biophysics·V Sudhakar ReddyG Bhanuprakash Reddy

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Methods Mentioned

BETA
transgenic
transgenics
irradiating

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