The protective effect of adrenocorticotropic hormone treatment against noise-induced hearing loss

Auris, Nasus, Larynx
Ahmet MutluLevent Ozluoglu

Abstract

NIHL is a common problem, and steroids are the most effective treatment option. In this study, we aimed to evaluate the protective effects of the synthetic adrenocorticotropic hormone (ACTH) analogues, which induce endogenous steroid secretion, against noise-induced hearing loss (NIHL) and to compare their effectiveness with that of steroid treatment. Twenty-four male Sprague-Dawley albino rats were divided into four subgroups as follows: group 1 (n=6) control, group 2 (n=6) saline, group 3 (n=6) dexamethasone (2mg/kg/day intramuscularly [IM]), group 4 (n=6) ACTH analogue (0,4mg/kg/day IM), respectively. Three groups (groups 2-4) were exposed to white noise (105dB SPL, 12h). All the rats were evaluated for hearing thresholds of 10kHz, 20kHz, and 32kHz via acoustic brainstem responses (ABR) measurement. After the basal threshold measurements, measurements were repeated immediately after the noise and on day 7 and day 21. Both steroid and ACTH analogue groups showed significantly better hearing outcomes than the saline group on day 7 (p<0.001) and day 21 (p<0.001) after the noise exposure. No superior treatment effect was demonstrated in either the steroid or ACTH analogue group. None of the related intervention groups reached th...Continue Reading

Citations

Aug 26, 2020·Expert Opinion on Drug Discovery·Isabel Varela-NietoLuis Lassaletta
Dec 5, 2019·The Journal of the Acoustical Society of America·Celia D EscabiEdward Lobarinas
Mar 30, 2021·Hormone Molecular Biology and Clinical Investigation·Shima AbabzadehDorsa Faghani

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