The protective effect of alpha-tocopherol and GdCl3 against hepatic ischemia/reperfusion injury.

Surgery Today
Dimitrios GiakoustidisDimitrios Takoudas

Abstract

To evaluate the combined effect of alpha-tocopherol and gadolinium chloride (GdCl3) in reducing lipid peroxidation after severe hepatic ischemia/reperfusion (IR) injury. Sixty male Wistar rats, 200-250 g, were randomly divided into six equal groups. There were two sham operation (SHAM) groups, two untreated IR groups, and two IR groups treated with GdCl3 and alpha-tocopherol (IRGT). After 60 min of total hepatic ischemia and 120 min reperfusion, one of each group was killed, liver samples were taken for malondialdehyde (MDA) and myeloperoxidase (MPO) analysis and light microscopy examination, and blood samples were analyzed for aspartate (AST) and alanine (ALT) transaminase, lactate dehydrogenase (LDH), and alpha-tocopherol content. The remaining groups were monitored for survival rate determination. The mean MDA and MPO values in the SHAM, IR, and IRGT groups, respectively, were 1.117, 1.476, and 0.978 nmol/g wet tissue and 1.49, 6.26, and 1.78 (U/g). The mean alpha-tocopherol values in the SHAM, IR, and IRGT groups, respectively, were 10.4, 1.9, and 12 micromol/l. The mean serum AST, ALT, and LDH values were significantly higher in the IR group than in the SHAM group (P < 0.001), and significantly lower in the IRGT group than...Continue Reading

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Citations

Dec 12, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Puja GulatiNirmal Singh
Jun 30, 2009·The Tohoku Journal of Experimental Medicine·Orhan Veli OzkanNizami Duran
Nov 15, 2008·Shock·Thiruma V ArumugamTrent M Woodruff
Jul 29, 2008·The Journal of Surgical Research·Gul DaglarNuri Aydin Kama
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May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yong ChenJianping Gong
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May 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Nov 30, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Meriem FerratBahia Djerdjouri
Sep 1, 2009·Korean journal of anesthesiology·Eun Ho LeeYu Mi Lee

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