The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)

Ecotoxicology and Environmental Safety
Zuoqing YuanWenpeng Xin

Abstract

The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15mg/L and anthocyanins at 10 or 20mg/L were individually and simultaneously administered to planarians for up to 10d. The results showed PFOA treatment induced an increase in mitochondrial permeability transition pore opening and a decrease antioxidant capacity and enzyme activities. In anthocyanin treated animals, the activity of succinate dehydrogenase, cytochrome oxidase and monoamine oxidase increased, but mitochondrial permeability transition pore opening decreased and total antioxidant capacity increased. An improvement in above-mentioned physiological and biochemical parameters was found in the combined PFOA and anthocyanin treated animals, in a dose-dependent manner. Anthocyanins attenuated the PFOA induced toxicity; antioxidant capacity and enzyme activities are involved in the protective mechanism of anthocyanins.

References

Nov 6, 1998·Japanese Journal of Pharmacology·Y KitamuraT Taniguchi
Dec 29, 2000·Phytochemistry·J B Harborne, C A Williams
Apr 25, 2002·Nature Reviews. Genetics·Philip A Newmark, Alejandro Sánchez Alvarado
May 23, 2002·Biochimie·Anne-Sophie BelzacqCatherine Brenner
Jan 23, 2003·Journal of Agricultural and Food Chemistry·Marja P Kähkönen, Marina Heinonen
Aug 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy M O'Brien, Kendall B Wallace
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
May 30, 2007·Molecular Nutrition & Food Research·Shirley Zafra-StoneDebasis Bagchi
Nov 16, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Melvin E AndersenKendall B Wallace
Feb 27, 2009·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
Oct 20, 2010·The British Journal of Nutrition·Gary Williamson, Michael N Clifford
Jan 5, 2011·BMC Genomics·Josep F AbrilEmili Saló
Apr 13, 2012·Toxicology and Industrial Health·Jianyong ZhangShudong Yang
Jul 6, 2014·Archives of Environmental Contamination and Toxicology·Jui-Pin WuMei-Hui Li
Dec 3, 2014·Chemico-biological Interactions·Dehong TanXinyue Luo
Aug 1, 1997·Redox Report : Communications in Free Radical Research·I F Benzie, J J Strain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.