The protective effect of cilostazol on isolated rabbit femoral arteries under conditions of ischemia and reperfusion: the role of the nitric oxide pathway.

Clinics
Mariana R G A SantosEdwaldo E Joviliano

Abstract

The clinical significance of ischemia/reperfusion of the lower extremities demands further investigation to enable the development of more effective therapeutic alternatives. This study investigated the changes in the vascular reactivity of the rabbit femoral artery and nitric oxide metabolites under partial ischemia/ reperfusion conditions following cilostazol administration. Ischemia was induced using infrarenal aortic clamping. The animals were randomly divided into seven groups: Control 90 minutes, Ischemia/Reperfusion 90/60 minutes, Control 120 minutes, Ischemia/Reperfusion 120/90 minutes, Cilostazol, Cilostazol before Ischemia/Reperfusion 120/90 minutes, and Ischemia 120 minutes/Cilostazol/ Reperfusion 90 minutes. Dose-response curves for sodium nitroprusside, acetylcholine, and the calcium ionophore A23187 were obtained in isolated femoral arteries. The levels of nitrites and nitrates in the plasma and skeletal muscle were determined using chemiluminescence. Acetylcholine-and A23187-induced relaxation was reduced in the Ischemia/Reperfusion 120/90 group, and treatment with cilostazol partially prevented this ischemia/reperfusion-induced endothelium impairment. Only cilostazol treatment increased plasma levels of nitrites...Continue Reading

Citations

Nov 2, 2013·The Journal of Surgical Research·Tuba AvciTolga Tatar
Jul 24, 2014·Clinical & Experimental Metastasis·Moritz J StrowitzkiMichael D Menger
Oct 17, 2019·International Journal of Molecular Sciences·Ricardo O S SoaresOrlando Castro-E-Silva
Jan 25, 2017·Oxidative Medicine and Cellular Longevity·Simón Quetzalcoatl Rodríguez-LaraLeonel García-Benavides
Jun 19, 2019·Marine Drugs·Marisol Zuluaga TamayoGraciela Pavon-Djavid
Aug 3, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Helmy MoawadMohammed A Alkhawlani
Jun 26, 2020·Cell Death & Disease·Weifeng YaoZiqing Hei
Oct 30, 2014·Acta Cirúrgica Brasileira·Carlos Alberto da Silva Frias NetoEdna Frasson de Souza Montero

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