The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury

Mediators of Inflammation
Jin LiFengzhong Wang

Abstract

As the major active ingredient ofCordyceps militaris, cordycepin (3'-deoxyadenosine) has been well documented to alleviate inflammation and oxidative stress both in vitro and in vivo. To explore the potential protective effect of cordycepin in fulminant hepatic failure, mice were pretreated with cordycepin for 3 weeks followed by D-galactosamine (GalN)/lipopolysaccharide (LPS) injection. Then we found cordycepin (200 mg/kg) administration elevated survival rate, improved liver function, and suppressed hepatocyte apoptosis and necrosis in mice with severe hepatic damage by GalN/LPS treatment. Further, cordycepin inhibited hepatic neutrophil and macrophage infiltration and prevented proinflammatory cytokine production possibly through suppressing TLR4 and NF-κB signaling transduction. The blockade of reactive oxygen species (ROS) and lipid peroxidation production by cordycepin was associated with the decrease of NAD(P)H oxidase (NOX) activity. Besides, cordycepin significantly prevented excessive autophagy induced by GalN/LPS in the liver. These data suggested that cordycepin could be a promising therapeutic agent for GalN/LPS-induced hepatotoxicity.

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Citations

Dec 6, 2017·World Journal of Gastroenterology : WJG·Lei FengYi Gao
Jun 28, 2019·Biochemical and Biophysical Research Communications·Tianjiao LiBijun Cheng
Feb 13, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tian LanJiao Guo

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Polymerase Chain Reaction
ELISA
MDA
electron macroscopy

Software Mentioned

Volocity

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