The protective effect of curcumin on ischemia-reperfusion-induced liver injury

Transplantation Proceedings
C M LinC L Su

Abstract

Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. The protocol resulted in elevation of blood NO (P < .001), TNF-α (P < .001), and MG (P < .001). sGOT, sGPT, and LDH were elevated significantly (P < .001), whereas ATP was significantly diminished (P < .001). Pretreatment with curcumin (25 mg/kg) significantly attenuated the reperfusion liver injury, while the ATP content reversed. In addition, MG, TNF-α, and NO relea...Continue Reading

References

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Citations

Feb 20, 2014·BioMed Research International·Erkan CureAhmet Fikret Yücel
Dec 3, 2013·Canadian Journal of Physiology and Pharmacology·Hala Fahmy Zaki, Rania Mohsen Abdelsalam
Sep 24, 2013·BMC Research Notes·Sameh S TawfikYasser E Shahein
Sep 19, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shengxian JiaThomas A Mustoe
Mar 13, 2014·Pharmaceutical Biology·Mona Fouad Mahmoud, Hany Mohamed El Bassossy
Nov 26, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Arumugam SuyavaranChinnasamy Thirunavukkarasu
Mar 19, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Arumugam Suyavaran, Chinnasamy Thirunavukkarasu
Dec 12, 2020·Annals of Medicine and Surgery·Georgios KyriakopoulosAlexandra K Tsaroucha
Oct 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sara A BrownKymberly D Watt

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