The protective effect of gamma-glutamyl L-dopa on the glycerol treated rat model of acute renal failure

Clinical Science
I F CassonM R Lee

Abstract

gamma-Glutamyl L-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no gamma-glutamyl L-dopa. The plasma creatinine in rats given gamma-glutamyl L-dopa and glycerol was significantly lower than in rats receiving glycerol alone. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by gamma-glutamyl L-dopa and the natriuresis abolished. gamma-Glutamyl L-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. The administration of gamma-glutamyl L-dopa reduces the severity of renal failure produced by glycerol.

Citations

Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·M R Lee
May 1, 1992·Clinical and Experimental Pharmacology & Physiology·Z Q WangB P McGrath
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·M R Lee
Nov 16, 2004·São Paulo Medical Journal = Revista Paulista De Medicina·Cláudia Nathalie PereiraJosé Luiz Gomes do Amaral
Aug 1, 1990·Journal of Clinical Pharmacology·P T Horn, M B Murphy
Apr 1, 1991·British Journal of Clinical Pharmacology·Y A BoatengM R Lee
Nov 5, 1998·Journal of Cardiothoracic and Vascular Anesthesia·S Aronson, R Blumenthal

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