Abstract
Ischemia-reperfusion (IR) injury remains an important clinical problem after lung transplantation. It is well-known that ischemic preconditioning (IPC) markedly enhances the ability of organs to withstand a sustained ischemia and reperfusion injury. But the molecular mechanisms of this protective effect are poorly understood. Therefore, we used gene microarrays to profile gene expression patterns involved in ischemia precondition. Three groups of rats were studied: IR group (IR 0, 1, 3, 6, 24, n = 5 each group, IPC group (IP 1, IP 3, 6, 24 h, n = 5 each group) and Sham group (n = 5). Samples were collected from different groups. The RatRef-12 expression Beadchip (22,226 gene probes per array) was used to analyze the pattern of gene expression in all groups. Microarray analysis showed that 648, 340, 711, 1279, and 641 genes were differentially expressed in IR 0-, 1-, 3-, 6- and 24-h groups, respectively. The profile revealed that IPC induced significant alterations of expression of many genes encoding inflammatory associated factors, oxidation and antioxidant molecules, apoptosis regulatory protein, metabolic enzyme, and ion channel protein. The damage and repair after lung IR are a dynamic process. IPC affects gene expression p...Continue Reading
References
Nov 1, 1986·Circulation·C E MurryK A Reimer
Oct 14, 1993·Nature·N SekidoK Matsushima
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·E P Trulock
Jul 15, 1997·The Journal of Clinical Investigation·R M ZwackaJ F Engelhardt
Sep 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·I FriedrichJ Borgermann
May 2, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shahrokh TaghaviSeyedhossein Aharinejad
Sep 25, 2002·Transplantation Proceedings·S BenzU T Hopt
Feb 15, 2003·FEBS Letters·Annamária OnodyLászló G Puskás
Sep 10, 2003·Transplantation Proceedings·C PeraltaJ Roselló-Catafau
Aug 31, 2004·Journal of Neuroscience Research·X-C May LuJitendra R Dave
Jan 6, 2005·American Journal of Physiology. Renal Physiology·David P BasileAllen W Cowley
Feb 1, 2005·World Journal of Gastroenterology : WJG·Shu-Feng WangKun Gao
Mar 9, 2005·Transplantation·Walter G Land
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Masaomi YamaneShaf Keshavjee
Sep 27, 2005·Digestive Diseases and Sciences·Yuji NaitoToshikazu Yoshikawa
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Philipp MarkartIvar Friedrich
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I BorozanI D McGilvray
Aug 22, 2006·Life Sciences·H Burak KandilciHoward Lippton
Oct 16, 2007·Life Sciences·Alistair B M Phillips, Wilson Ko
Aug 8, 2008·Current Opinion in Organ Transplantation·Shohachi SuzukiHiroyuki Konno
Mar 3, 2009·Transplantation Proceedings·R P JiaL W Xu
Citations
Mar 17, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Carlos SimónFederico González-Aragoneses
Aug 11, 2012·PloS One·Vicki L MahanFrank A Pigula
May 25, 2013·PloS One·Nadine BrewRichard Harding
Jun 20, 2013·American Journal of Respiratory and Critical Care Medicine·Anthony W CastleberryMatthew G Hartwig
Jun 9, 2015·Experimental Lung Research·Chou-Chin LanChin-Pyng Wu
Aug 2, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Min Gao, Donglei Liu
Oct 22, 2015·PloS One·Young Eun YoonWoong Kyu Han
Sep 20, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Peter DromparisBenjamin A Adam
Jul 10, 2013·Experimental and Therapeutic Medicine·Cimen Gülben OlgunerSerap Cilaker Micili
Jul 22, 2020·Journal of Anesthesia·Zhaosheng JinDaqing Ma