The Protective Effect of Naringenin on Oxaliplatin-Induced Genotoxicity in Mice

Chemical & Pharmaceutical Bulletin
Majid A GanaieIshfaq A Sheikh

Abstract

Oxaliplatin is a third generation platinum based anti-cancer drug used against various human malignancies but displays genotoxic properties against normal cells. Naringenin is a naturally occurring bioflavonoid that possesses anti-oxidant properties and has protective effects against DNA damage. The aim of this study is to examine the protective effects of naringenin on oxaliplatin-induced DNA damage in mice. A total of 50, male BALB/c mice were randomly divided equally into five groups. Oxaliplatin toxicity was induced by a single dose (7 mg/kg body weight (b.w.)) injection (intraperitoneally (i.p.)) of oxaliplatin. Naringenin was given orally for ten consecutive days at two doses, 20 mg/kg b.w. (dose I) and 40 mg/kg b.w. (dose II), to group I and group II, respectively. On the tenth day of the experiment, animals in groups III, IV, and V were given a single i.p. injection of oxaliplatin (7 mg/kg b.w.). All the animals were sacrificed 24 h after oxaliplatin treatment. The extent of genotoxicity was assessed by multiple genotoxicity assays (8-hydroxydeoxy-guanosine marker, comet, micronucleus and chromosomal aberration assays, oxidative stress-marker Glutathione evaluation) in order to determine diverse kinds of DNA damage. The...Continue Reading

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Citations

Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Mar 17, 2021·Phytotherapy Research : PTR·Karim NarakiGholamreza Karimi
May 30, 2021·Bulletin of Experimental Biology and Medicine·N V EreminaA D Durnev
Aug 30, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Natacha AllgayerMauricio Lehmann

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