The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat

S SakakibaraH Kagamiyama


A marked increase of serum transaminase activities, histological changes of livers similar to those seen in viral hepatitis in man, and inhibition of hepatic protein synthesis were observed in rats following a single injection of D-galactosamine-HCl. These galactosamine-induced phenomena were prevented by the pretreatment of polyriboinosinic acid-polyribocytidylic acid 24 h before the galactosamine administration.


Sep 2, 1976·The New England Journal of Medicine·H B GreenbergT C Merigan
Jan 1, 1974·Reviews of Physiology, Biochemistry and Pharmacology·K Decker, D Keppler
Oct 1, 1968·Experimental and Molecular Pathology·D KepplerK Decker
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A K FieldM R Hilleman
Jan 1, 1955·The Journal of Clinical Investigation·A KARMENJ S LADUE
May 18, 1973·Science·S BaronJ S Younger

Related Concepts

Poly ICLC, sodium salt
SGPT - Glutamate pyruvate transaminase
Aspartate Transaminase
Liver Dysfunction

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