The Protective Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Ethanol-induced Damage in Cultured Feline Esophageal Epithelial Cells.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jung Hyun ChoUy Dong Sohn

Abstract

Quercetin-3-O-β-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. We aimed to explore its protective effect against ethanol-induced cell damage and the mechanism involved in the effect in feline esophageal epithelial cells (EEC). Cell viability was tested and 2',7'-dichlorofluorescin diacetate assay was used to detect intracellular H(2)O(2) production. Western blotting analysis was performed to investigate MAPK activation and interleukin 6 (IL-6) expression. Exposure of cells to 10% ethanol time-dependently decreased cell viability. Notably, exposure to ethanol for 30 min decreased cell viability to 43.4%. When cells were incubated with 50 µM QGC for 12 h prior to and during ethanol treatment, cell viability was increased to 65%. QGC also inhibited the H(2)O(2) production and activation of ERK 1/2 induced by ethanol. Pretreatment of cells with the NADPH oxidase inhibitor, diphenylene iodonium, also inhibited the ethanol-induced ERK 1/2 activation. Treatment of cells with ethanol for 30 or 60 min in the absence or presence of QGC exhibited no changes in the IL-6 expression or release compared to control. Taken together, the data indicate that the cytoprotective effect of QGC against ethan...Continue Reading

References

Jul 1, 1992·Gastroenterology·H TilgC Huber
Jul 1, 1988·Digestive Diseases and Sciences·I Szelenyi, K Brune
Jun 1, 1972·Journal of Applied Physiology·W J HoganD H Winship
Jan 1, 1994·Advances in Experimental Medicine and Biology·C Kandaswami, E Middleton
Jun 1, 1994·Alcoholism, Clinical and Experimental Research·D J Bjorkman, L D Jessop
Nov 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TilgC A Dinarello
Mar 15, 1997·Experimental Cell Research·L Shapiro, C A Dinarello
Sep 12, 1998·Nature Medicine·M P SoaresF H Bach
Jan 1, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C HanckM V Singer
Jul 7, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L GatéH Tapiero
Aug 5, 2000·Journal of Natural Products·P G Pietta
Feb 22, 2001·Free Radical Biology & Medicine·Y LiM A King
Mar 10, 2001·Nature·L Chang, M Karin
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Feb 14, 2002·Planta medica·Guido Jürgenliemk, Adolf Nahrstedt
Apr 18, 2002·Free Radical Biology & Medicine·Masayuki Adachi, Hiromasa Ishii
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Stephan Teyssen, Manfred V Singer
Dec 5, 2003·Life Sciences·Keiko MorikawaShigeru Morikawa
Mar 19, 2004·Life Sciences·Annayya R Aroor, Shivendra D Shukla
Mar 31, 2004·Molecular Aspects of Medicine·Osvaldo R KochTommaso Galeotti
Mar 31, 2004·The Journal of Nutrition·Gudrun ReitererBernhard Hennig
Jun 8, 2004·Current Medicinal Chemistry·T TakahashiS Sassa
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Hailan ZhouGary A Visner
Jul 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Weibiao CaoKaren M Harnett
Nov 20, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ling ChengKaren M Harnett
May 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ling ChengKaren M Harnett
Oct 18, 2005·Experimental Gerontology·João Pedro de Magalhães, George M Church
Nov 15, 2005·American Journal of Respiratory Cell and Molecular Biology·John A PolikandriotisC Michael Hart
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Tomás Zima, Marta Kalousová
Mar 2, 2006·Digestive Diseases·Andreas FrankeManfred V Singer
Mar 2, 2006·Digestive Diseases·Rajkumar Rajendram, Victor R Preedy
Aug 11, 2006·Alcoholism, Clinical and Experimental Research·Gennadiy NovitskiyEsteban Mezey
Aug 23, 2006·Oncogene·S G Menon, P C Goswami
Oct 14, 2006·Molecular Nutrition & Food Research·Jingli ZhangMargot A Skinner
Dec 21, 2006·Journal of Agricultural and Food Chemistry·Lisu WangMing-Jiuan Wu

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Citations

Sep 19, 2015·Journal of Ethnopharmacology·Andrea VasasJudit Hohmann
Sep 3, 2016·Journal of Toxicology and Environmental Health. Part a·Cristiano TrindadeJoão Antonio Pêgas Henriques
Dec 28, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Juho JungUy Dong Sohn
Jul 18, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Thanh-Do LeHoon Yoo
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Se Eun LeeUy Dong Sohn

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