The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose

Journal of Diabetes and Its Complications
Ludovica PiconiA Ceriello

Abstract

In diabetes the exposure of the vascular endothelium to high glucose levels results in increased oxidative insult and in vascular dysfunction. We have investigated the effects of rosuvastatin on oxidative stress and apoptosis induced in human umbilical vein endothelial cells (HUVECs) by constant and intermittent high glucose levels. HUVECs were incubated for 14 days in either low (5 mM) or high (20 mM) glucose concentrations, or intermittent high and low glucose on a daily basis. Constant high glucose levels increased p47-phox, p67-phox, and p22-phox expression [components of the Nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase complex]; endothelial nitric oxide synthase, nitric oxide, and O(2)(-) production; nitrotyrosine, 8-hydroxy-2'-deoxyguanosine, and caspase-3 expression; and reduced Bcl-2 expression. These effects were significantly greater under intermittent compared to constant high/low glucose conditions. The effect of rosuvastatin (1 microM) in the presence or absence of mevalonate (200 microM) was evaluated in the cells under both constant and intermittent glucose conditions. Rosuvastatin almost normalized all these parameters. These effects of rosuvastatin were prevented when mevalonate was also added,...Continue Reading

References

Jul 31, 1998·Archives of Biochemistry and Biophysics·H Ischiropoulos
Sep 3, 1998·The Journal of Biological Chemistry·U Laufs, J K Liao
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaR P Robertson
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sergey V BrodskyMichael S Goligorsky
Jul 10, 2004·Current Opinion in Lipidology·Jane Armitage, Louise Bowman
Oct 27, 2004·Archives of Internal Medicine·Antonio CerielloJaakko Tuomilehto

❮ Previous
Next ❯

Citations

May 8, 2013·European Journal of Pharmacology·Rajkiran Mahalwar, Deepa Khanna
May 27, 2014·Journal of Endocrinological Investigation·Ting-song LiuJian-bin Gong
Jan 2, 2016·Pharmacological Reports : PR·Mariola HerbetEwa Jagiełło-Wójtowicz
Feb 13, 2009·British Journal of Pharmacology·Csaba Szabo
Jan 12, 2010·Atherosclerosis·Niki KatsikiApostolos I Hatzitolios
Jul 9, 2011·Stroke; a Journal of Cerebral Circulation·Yoshiteru TadaShinji Nagahiro
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Debashish MondolMd Rafiqul Islam
May 25, 2021·Frontiers in Cell and Developmental Biology·Yingzhen ZhangXiaoyun Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.