The protective effect of some phenothiazine derivatives against streptolysin O

British Journal of Pharmacology
D BesluauB N Halpern

Abstract

1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.

Citations

Jan 1, 1973·Biochimie·J E Alouf, M Raynaud
Jun 1, 1972·Experimental Cell Research·G Poste, P Reeve
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·B N Halpern, S Rahman
May 6, 1969·Biochimica Et Biophysica Acta·S RahmanD Besluau
May 1, 1964·Journal of Bacteriology·A W Bernheimer, L L Schwartz
Oct 1, 1966·The Journal of Experimental Medicine·J B Zabriskie, E H Freimer
Sep 1, 1956·The Journal of Experimental Medicine·A W BernheimerA KELLNER
Apr 1, 1961·The Journal of Experimental Medicine·S P HALBERTE DAHLE

Related Concepts

Antipsychotic Effect
streptolysin O antigen
Subcutaneous Injections
Streptolysin O
Smith-Lemli-Opitz Syndrome
Chlorpromazine
Streptolysins
Lethal Dose 50
Promethazine
Phenothiazine derivatives

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