The protective effect of some phenothiazine derivatives against streptolysin O

British Journal of Pharmacology
D BesluauB N Halpern


1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.


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Related Concepts

Antipsychotic Effect
streptolysin O antigen
Subcutaneous Injections
Streptolysin O
Smith-Lemli-Opitz Syndrome
Lethal Dose 50
Phenothiazine derivatives

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