The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1

The Journal of Pharmacology and Experimental Therapeutics
Carolina MuscoliVincenzo Mollace

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the principal receptor for oxidized low-density lipoprotein (ox-LDL) in vascular endothelial cells (ECs), has recently been suggested to exert a pivotal role in atherogenesis, possibly by mediating ox-LDL-evoked endothelial dysfunction. On the other hand, LOX-1 expression seems to strongly correlate with the oxidative stress occurring in the vascular wall of experimentally injured blood vessels. Here, we investigated LOX-1 expression and superoxide generation during neointima formation in a balloon injury rat carotid artery model. To test this, we used M40401 [a manganese(II) complex with a bis(cyclo-hexylpyridine-substituted) macrocyclic ligand], a synthetic superoxide dismutase mimetic that is a selective scavenger of superoxide. The injury was performed inserting the balloon catheter through the rat common carotid artery and after 14 days a histopathological analysis revealed a significant restenosis with smooth muscle cell proliferation and neointima formation that was associated with an enhanced expression of LOX-1, nitrotyrosine (the footprint of peroxynitrite) staining, and lipid peroxidation as assessed by malondialdehyde (MDA) formation. Pretreatment of r...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S D CushingA M Fogelman
Jun 30, 1988·The New England Journal of Medicine·W McBrideL D Hillis
Sep 12, 1974·The New England Journal of Medicine·L A HarkerR Ross
Jan 14, 1999·The New England Journal of Medicine·R Ross
Oct 16, 1999·Circulation Research·C Kunsch, R M Medford
Mar 10, 2001·Biochemical and Biophysical Research Communications·M NagaseT Fujita
Jun 20, 2001·Trends in Cardiovascular Medicine·N Kume, T Kita
May 3, 2002·Journal of the American College of Cardiology·Jawahar L Mehta, Dayuan Li
Jul 18, 2002·Nature Reviews. Drug Discovery·Daniela SalveminiSalvatore Cuzzocrea
Oct 3, 2003·British Journal of Pharmacology·Carolina MuscoliDaniela Salvemini

❮ Previous
Next ❯

Citations

Aug 10, 2011·Cardiovascular Drugs and Therapy·Jawahar L MehtaTatsuya Sawamura
Feb 23, 2011·Antioxidants & Redox Signaling·Jingjun LuJawahar L Mehta
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Irfan Rahman
Feb 13, 2007·Trends in Cardiovascular Medicine·Christopher A Papaharalambus, Kathy K Griendling
Jan 26, 2006·Biochemical and Biophysical Research Communications·Hideyuki EtoChuwa Tei
Feb 7, 2006·Pharmacology & Therapeutics·Paul Kirkham, Irfan Rahman
Feb 22, 2012·Current Opinion in Pharmacology·Irfan Rahman, William MacNee
Jan 27, 2015·Redox Biology·Rommel C MoralesMelina R Kibbe
Feb 26, 2013·Metabolism: Clinical and Experimental·Michiaki FukuiNaoto Nakamura
Nov 22, 2011·Biochimica Et Biophysica Acta·Irfan Rahman
Sep 18, 2008·Angiology·Selvaraj NambiarSridhar Gopalakrishna Magadi
Apr 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Michel Félétou, Paul M Vanhoutte
Jun 16, 2012·Expert Review of Clinical Pharmacology·Irfan Rahman, Vuokko L Kinnula
Jul 7, 2019·International Journal of Molecular Sciences·Micaela GliozziVincenzo Mollace
Nov 20, 2008·Archives of Biochemistry and Biophysics·Daniela Salvemini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.