The protective effect of syringic acid on ischemia injury in rat brain

Turkish Journal of Medical Sciences
Mustafa GuvenMurat Cosar

Abstract

Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic acid group sacrificed at 24 h. Obtained brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after syringic acid treatment, while increased malondialdehyde levels after ischemia were reduced after treatment. Caspase-3 and caspase-9 values increased after ischemia and decreased after treatment; this reduction was more pronounced at 24 h. Our study revealed that syringic acid treatment in cerebral ischemia reduced oxidative stress...Continue Reading

Citations

Apr 5, 2016·BioMed Research International·Jae Yeon LeeSeok Hwa Choi
May 11, 2017·Nutrients·Dominik SzwajgierKatarzyna Pustelniak
Mar 30, 2019·Human & Experimental Toxicology·S Gheena, D Ezhilarasan
Jan 24, 2019·Journal of Cellular Physiology·Mehran PashirzadSeyed Mahdi Hassanian
Jun 10, 2016·International Journal of Molecular Medicine·Yidong CaoDong Jia
Nov 22, 2019·Acta Biochimica Et Biophysica Sinica·Yaofa LinHaodong Lin
Aug 25, 2019·Antioxidants·Aimee N Winter, Paula C Bickford
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ipek SüntarLuciano Saso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.