The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway

Oxidative Medicine and Cellular Longevity
Yang LuoKe Yuan

Abstract

Abelmoschus esculentus L. has favorable nutritional/medicinal features. We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A. esculentus; according to high-performance liquid chromatography, the quercetin-3-O-[β-D-glu-(1 → 6)]-β-D-glucopyranoside content was 122.13 mg/g. Protective effects of an extract of the total flavonoids of A. esculentus flowers (AFF) on transient cerebral ischemia-reperfusion injury (TCI-RI) were investigated. Compared with the model group, mice treated with AFF (300 mg/kg) for 7 days showed significantly reduced neurologic deficits, infarct area, and histologic changes in brain tissue, accompanied by increased contents of superoxide dismutase, whereas contents of nitric oxide and malondialdehyde decreased. AFF upregulated the expression of Nrf2, HO-1, and NQO1. These data suggest that AFF protects against TCI-RI by scavenging free radicals and activating the Nrf2-ARE pathway.

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Citations

Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Liangkai ChengCaiyan Wang
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kicinska, Wieslawa Jarmuszkiewicz
Nov 3, 2020·Veterinary World·Sri Puji Astuti WahyuningsihManikya Pramudya
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alena LiskovaPeter Kubatka
Jul 6, 2021·Veterinary Medicine International·Sri Puji Astuti WahyuningsihBrigita Klara Krisdina Mamuaya

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Methods Mentioned

BETA
protein assay
MDA
ubiquitination

Software Mentioned

Image
SPSS
Pro Plus

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