The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts

Progress in Biophysics and Molecular Biology
Francisca SchultzJulia Gorelik

Abstract

Bile acids are elevated in the blood of women with intrahepatic cholestasis of pregnancy (ICP) and this may lead to fetal arrhythmia, fetal hypoxia and potentially fetal death in utero. The bile acid taurocholic acid (TC) causes abnormal calcium dynamics and contraction in neonatal rat cardiomyocytes. Ursodeoxycholic acid (UDCA), a drug clinically used to treat ICP, prevents adverse effects of TC. During development, the fetus is in a state of relative hypoxia. Although this is essential for the development of the heart and vasculature, resident fibroblasts can transiently differentiate into myofibroblasts and form gap junctions with cardiomyocytes in vitro, resulting in cardiomyocyte depolarization. We expanded on previously published work using an in vitro hypoxia model to investigate the differentiation of human fetal fibroblasts into myofibroblasts. Recent evidence shows that potassium channels are involved in maintaining the membrane potential of ventricular fibroblasts and that ATP-dependent potassium (KATP) channel subunits are expressed in cultured fibroblasts. KATP channels are a valuable target as they are thought to have a cardioprotective role during ischaemic and hypoxic conditions. We investigated whether UDCA cou...Continue Reading

References

Apr 10, 1976·British Medical Journal·R ReidB Storey
Dec 13, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W H SepúlvedaM I Rudolph
Feb 24, 2001·Pflügers Archiv : European journal of physiology·J P Ruppersberg
Aug 13, 2002·The Journal of Biological Chemistry·Ulf LangeUlrich Quast
May 14, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·J GorelikC Williamson
Jun 12, 2003·Cardiovascular Research·Sumihiko SekiNoritsugu Tohse
Jul 24, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·J GorelikC Williamson
Sep 1, 2004·Biochemical and Biophysical Research Communications·Mark Scoote, Alan J Williams
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna GlantzLars-Ake Mattsson
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·L ChiltonW R Giles
Mar 15, 2005·Biophysical Journal·Yoshiyuki ShibukawaWayne R Giles
Mar 11, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Al IniziA Gale
Apr 28, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J GorelikC Williamson
Oct 24, 2006·Cardiovascular Research·Julia GorelikSian E Harding
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Oct 30, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·William S Webster, Dominique Abela
Dec 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kenneth B Walsh, Jining Zhang
Sep 4, 2008·Fetal Diagnosis and Therapy·Antonia W ShandLuigi D'Orsogna
Jan 27, 2009·Journal of Molecular and Cellular Cardiology·Najate BenamerJean-François Faivre
Apr 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alexander R LyonJulia Gorelik
May 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emina HalilbasicMichael Trauner
Oct 13, 2009·Journal of Molecular and Cellular Cardiology·Andrew P ZimanW J Lederer
Feb 4, 2010·Current Opinion in Obstetrics & Gynecology·Jonathan K Mays
Aug 18, 2010·Current Molecular Medicine·A J Patterson, L Zhang
Jul 30, 2011·Skeletal Muscle·Lama Al-Qusairi, Jocelyn Laporte
Aug 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michele MiragoliJulia Gorelik
Feb 4, 2012·Journal of the American College of Cardiology·Stephan von HaehlingStefan D Anker
Feb 26, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Najate BenamerGregory E Morley
Oct 26, 2014·Cardiovascular Research·Teddy GrandStephan Rohr
Aug 1, 2015·BioMed Research International·Michele Miragoli, Alexey V Glukhov

❮ Previous
Next ❯

Citations

Feb 22, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Andrei VoiosuSøren Møller
May 17, 2017·Molecular Aspects of Medicine·Saraid McIlvrideCatherine Williamson
Jan 17, 2016·Progress in Biophysics and Molecular Biology·Roland F R Schindler, Thomas Brand
Apr 30, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vanessa PataiaCatherine Williamson
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francisca SchultzJulia Gorelik
Feb 6, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·M CauldwellC Williamson
Jul 2, 2021·Canadian Journal of Gastroenterology & Hepatology·Jianping XiaoYan Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.