The protective effect of Yi-Qi-Yang-Yin-Ye, a compound of traditional Chinese herbal medicine in diet-induced obese rats

The American Journal of Chinese Medicine
Guang-Wei HeRong He

Abstract

The present study was undertaken to determine the effect of Yi-Qi-Yang-Yin-Ye (Y-Q-Y-Y-Y), a compound of Traditional Chinese Herbal Medicine, on insulin resistance (IR) in the diet-induced obese rat model induced by intravenous injection with a low dose of streptozotocin and fed a high fat and high caloric diet. Y-Q-Y-Y-Y (2, 4, 8 g/kg) was administered via gavage daily for 4 weeks. The results showed that Y-Q-Y-Y-Y treatment decreased the levels of body weight, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), free fatty acid (FFA), insulin (INS) and fast blood glucose (FBG) and increased the level of high density lipoprotein-cholesterol (HDL-C) in the diet-induced obese rats. Glucose tolerance was improved in the diet-induced obese rats treated with Y-Q-Y-Y-Y as well as GIR (glucose infusion rate) in the hyperinsulinemic euglycemic clamp experiment compared to the model control rats (p < 0.01). Moreover, treatment with Y-Q-Y-Y-Y up-regulated glycogen contents in both liver and skeletal muscle and increased insulin receptor amounts on the erythrocytes surface as assessed by using (125)I-labeled auto-antibodies against insulin receptors. Taken together, our data suggested that Yi-Qi-Yang-Y...Continue Reading

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Citations

Jul 4, 2009·World Journal of Gastroenterology : WJG·Shirin Hasani-RanjbarMohammad Abdollahi
Oct 30, 2013·Clinical and Experimental Hypertension : CHE·Qiang YangWenjian Wang
Dec 18, 2014·BMC Complementary and Alternative Medicine·Heon-Myung LeeHyo-Jin An
Jun 24, 2014·The Cochrane Database of Systematic Reviews·Tae-Hun KimEdzard Ernst
Aug 19, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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