The protective effects of Arctium lappa L. Extract on testicular injuries induced by ethanol in rats

Andrologia
Siamak YariSeyed Hamed Moazzami Farida

Abstract

The aim of this study is to assess the antioxidant activity and also protective effects of Arctium lappa L. (AL) extract on ethanol-induced testicular injuries in rats. In addition, the total phenol and flavonoid contents of the methanolic extracts were analysed and the antioxidant activity of the extract was investigated. The studied extract possessed strong antioxidant activity (IC50 ; 0.113 ± 0.007 mg/ml) and exhibited more active than the ascorbic acid (IC50 ; 0.142 ± 0.002 mg/ml). The histological examinations revealed that the co-administration of ethanol and AL extract inhibits the testicular injuries, alterations in superoxide dismutase (SOD) activity, and H2 O2 and malondialdehyde (MDA) levels were observed in ethanol-treated rats in comparison to the control group. The obtained results demonstrated strong pharmaceutical activities of AL and its potential capacity to be developed as a new health-care supplement against ROS-related substances.

References

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·F Shahidi, P K Wanasundara
Jan 1, 1990·Free Radical Biology & Medicine·Y Sun
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·R NordmannH Rouach
Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·A Galvão-TelesE Monteiro
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Apr 1, 1997·Physiological Reviews·C S Lieber
Sep 26, 2000·Alcoholism, Clinical and Experimental Research·A ColantoniD H Van Thiel
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Sep 19, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P ValentãoM L Bastos
Apr 28, 2004·Molecular and Cellular Endocrinology·P VernetJ R Drevet
Mar 15, 2005·Clinics in Liver Disease·Charles S Lieber
May 12, 2005·Journal of Agricultural and Food Chemistry·Ronald L PriorKaren Schaich
Dec 3, 2005·International Journal of Antimicrobial Agents·T P Tim Cushnie, Andrew J Lamb
Jul 19, 2006·Drug Discovery Today·Hong-Yu ZhangGuang-Yan Tang
Jan 1, 2008·Journal of Ethnopharmacology·Filomena ConfortiRoberto Della Loggia
Apr 21, 2009·Journal of Pharmaceutical and Biomedical Analysis·Rosalia FerracaneAlberto Ritieni
Aug 5, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meltem KurusAli Otlu
Jan 16, 2010·Journal of Integrative Plant Biology·Charles S BuerMichael A Djordjevic
Oct 29, 2010·Inflammopharmacology·Yuk-Shing ChanShun-Wan Chan
Jan 11, 2011·Trends in Pharmacological Sciences·Barry Halliwell
Jul 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·M ManeeshD M Vasudevan
Jun 10, 2014·Andrologia·M Reshma Anjum, P Sreenivasula Reddy
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Mahmoud BahmaniKourosh Saki
Apr 6, 2016·Journal of Nephropathology·Babak Baharvand-AhmadiMahmoud Rafieian-Kopaei

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Citations

Jul 29, 2020·Andrologia·Nareelak Tangsrisakda, Sitthichai Iamsaard

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