Abstract
Disturbed intellectual function is an important determinant of long-term recovery after head injury. Residual behavioral disability depends largely upon which hemisphere is damaged and the site of injury within the hemisphere. Resulting neurobehavioral syndromes vary with the pattern of brain insult. While this correlation is important, it is still not well understood how damage to single neurons translates into abnormal behavior. In addition, no currently available technology permits in vivo evaluation of such cells in normal or injured states. While research into brain trauma traditionally emphasize single cell pathology, this level of study is insufficient to clarify how individual cell activity contributes to higher cognition. In contrast, neural network simulations may partially fill this void by predicting biological function. Here, we present data generated by a three-layer neural network that employs the ALOPEX algorithm, capable of learning 10 words. The addition of Gaussian distributed noise into connection weights strengths damaged the network's function; interestingly, the rate and extent of network impairment depended upon the level of learning that occurred during the training period, in agreement with human studi...Continue Reading
References
Nov 1, 1979·Annals of Neurology·M E PhelpsD E Kuhl
Jul 1, 1979·Behavioral and Neural Biology·W T GreenoughF R Volkmar
Jan 1, 1979·Biological cybernetics·E TzanakouE Harth
Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·S M Zeki
May 1, 1992·Journal of Experimental Psychology. Human Perception and Performance·S M KosslynO Koenig
Apr 1, 1990·Annals of Neurology·M Y ZhangP Levy
May 1, 1988·Trends in Neurosciences·E A DeYoe, D C Van Essen
Feb 25, 1988·Nature·D Zipser, R A Andersen
Jun 2, 1988·Nature·S R Lehky, T J Sejnowski
Jan 1, 1972·Journal of Neurophysiology·C G GrossD B Bender
Jul 1, 1969·Vision Research·B G Cragg
Sep 1, 1982·Neurology·J C MazziottaD E Kuhl
Apr 1, 1982·Archives of Neurology·H A SackeimN Geschwind
Apr 6, 1994·JAMA : the Journal of the American Medical Association·Y SternR Mayeux