The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.

Orthopaedic Surgery
Li-Tao ShaoLiu Zhang

Abstract

To assess the effects of PTH (1-34) on bone and cartilage metabolism in a collagenase-induced mouse model of osteoarthritis (OA) and examine whether PTH (1-34) affects the expression of JAK2/STAT3 and WNT5A/ROR2 in this process. Eighteen 12-week-old male C57Bl/6 mice were randomly assigned into three groups as follows: sham group (Group A), the collagenase + saline injection group (Group B), and the collagenase + PTH (1-34) treatment group (Group C). Collagenase was injected (intra-articular) into the knee joint of Group B and C. The PTH (1-34)-treatment was started at 6 weeks after the operation and lasted for 6 weeks. Cartilage pathology was evaluated by gross visual, histological, and immunohistochemical assessments. Subchondral bone was evaluated by microcomputed tomography (micro-CT) and immunohistochemical analyses. The OARSI macroscopic and microscopic scores of Group B were higher than those of Group A (P = 0.026; P = 0.002, respectively). Group C showed statistically significant differences in macroscopic and microscopic scores from Group B (P = 0.041; P = 0.008, respectively). The results showed that the Col-II and AGG expression levels in the cartilage tissue were significantly lower in Group B than Group A (P < 0.00...Continue Reading

References

Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C C Liu, D N Kalu
Jan 8, 2005·Clinics in Sports Medicine·Andrew D PearleScott A Rodeo
Jan 13, 2009·Bone·Frank P LuytenRik J Lories
Dec 4, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Erik Kern HarringtonKathy K H Svoboda
Apr 16, 2010·Annals of the New York Academy of Sciences·Mary B Goldring, Steven R Goldring
Jan 5, 2011·Protein & Cell·Edward A Lin, Chuan-Ju Liu
Apr 27, 2011·International Journal of Rheumatic Diseases·Carla M ThomasMohammed Sharif
Aug 19, 2011·Cellular & Molecular Biology Letters·Jia Gu HuangBing Zhang
Aug 8, 2012·Nature Reviews. Rheumatology·David B Burr, Maxime A Gallant
Mar 12, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Sara Hosseini-FarahabadiJoy M Richman
Jun 6, 2013·Biomechanics and Modeling in Mechanobiology·Corinne R HenakJeffrey A Weiss
Dec 8, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yu UsamiMotomi Enomoto-Iwamoto
Oct 19, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan ChenX Edward Guo
Nov 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zi-Zhou YaoXiang-Sheng Liu
Jan 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie LiuGang Wang
Apr 14, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mingjian BeiLiu Zhang
Aug 20, 2019·Cell Communication and Signaling : CCS·Yudan WangFaming Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.