The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells.

Neurotoxicity Research
Tao WangHu Sun

Abstract

Anesthetic-induced cognitive impairment has been observed clinically. The mechanism underlying anesthetic-induced cognitive impairment is closely associated with neuronal apoptosis and neuroinflammation. Ramelteon is a potent and highly selective melatonin receptor agonist that has been used for the treatment of insomnia and has been reported to have an anti-inflammatory effect. In this study, we aimed to investigate the protective effects of Ramelteon against the cytotoxicity induced by isoflurane in brain microvascular endothelial cells. Our results show that Ramelteon ameliorated oxidative stress by suppressing the generation of mitochondrial reactive oxygen species (ROS) in human brain microvascular endothelial cells (HBMVECs). In addition, Ramelteon displayed a robust anti-inflammatory capacity against isoflurane-induced insults and inflammation by reducing the generation of interleukin-1β (IL-1β), transforming growth factor-β (TGF-β), monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor-1 (SDF-1), matrix metalloproteinase-2 (MMP-2), and MMP-9. Furthermore, Ramelteon reduced the expression of cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and E-selectin. Importantly, Ramelteon dow...Continue Reading

References

Jun 3, 1982·Brain Research·C Crone, S P Olesen
Sep 5, 2003·Cell and Tissue Research·Britta Engelhardt
Mar 7, 2007·British Journal of Pharmacology·P S Whitton
Dec 25, 2007·Journal of Neurosurgical Anesthesiology·Stephen A JohnsonJohn W Olney
Jan 14, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Changlian ZhuKlas Blomgren
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Mar 2, 2011·Current Neuropharmacology·Emanuela Esposito, Salvatore Cuzzocrea
Oct 5, 2011·Pediatrics·Randall P FlickDavid O Warner
Dec 23, 2011·Annals of Neurology·Niccolò TerrandoMervyn Maze
May 25, 2013·Molecular and Cellular Endocrinology·Naoko TsukamotoHirofumi Makino
Sep 11, 2014·International Journal of Molecular Sciences·Moshe Laudon, Anat Frydman-Marom
Oct 8, 2015·Trends in Neurosciences·Brian Wai Chow, Chenghua Gu
Aug 24, 2016·The Eurasian Journal of Medicine·Mucahit EmetAhmet Hacimuftuoglu
Aug 12, 2020·Frontiers in Neuroendocrinology·Zhangsen HuangChenju Yi
Aug 28, 2020·International Journal of Molecular Sciences·Tao Ming SimDinesh Kumar Srinivasan
Sep 13, 2020·Neurobiology of Disease·Erwin A van VlietAsla Pitkänen

❮ Previous
Next ❯

Software Mentioned

image J

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Asian Journal of Psychiatry
Chintan Shah, Anita Kablinger
The Annals of Pharmacotherapy
Jill N ReynoldsonLeigh Anne Nelson
Journal of Central Nervous System Disease
Seithikurippu R Pandi-PerumalRüdiger Hardeland
© 2021 Meta ULC. All rights reserved