The Protective Effects of Vitamins A and E on Titanium Dioxide Nanoparticles (nTiO2)-Induced Oxidative Stress in the Spleen Tissues of Male Wistar Rats.

Biological Trace Element Research
Mozhgan Afshari-KavehNasrin Ziamajidi

Abstract

Titanium dioxide nanoparticles (nTiO2) can accumulate in different tissues and damage them with oxidative stress induction. Different components with antioxidant capacity can protect the tissues. So in this study, the protective effects of vitamin A and E on the nTiO2-induced oxidative stress in rats' spleen tissues were examined. Thirty-six male Wistar rats were randomly divided into 6 groups: Control 1 (received water), nTiO2, nTiO2 + vitamin E, nTiO2 + vitamin A, nTiO2 + vitamin A and E, and Control 2 (received olive oil). To investigate the status of oxidative stress, total antioxidant capacity (TAC), total oxidant status (TOS), and lipid peroxidation (LPO) were determined in spleen tissue as well as the activities of antioxidant enzymes, including glutathione peroxidase (GPx) and superoxide dismutase (SOD). Also, the gene expression of GPx, SOD, and nuclear factor-E2-related factor-2 (Nrf-2) were determined by qRT-PCR. To evaluate the spleen histopathological changes, H&E staining was carried out. nTiO2 significantly increased TOS and LPO levels, whereas it decreased TAC level, GPx and SOD activities, and gene expression of GPx, SOD, and Nrf-2 in spleen tissues of rats compared with controls (p < 0.05). In vitamin-treated ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1992·Trends in Biochemical Sciences·M LeidP Chambon
Apr 28, 1999·Free Radical Biology & Medicine·V P PalaceP K Singal
Nov 29, 2001·Photochemistry and Photobiology·R AckroydM Reed
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·S M Kashif R Zaidi, Naheed Banu
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Ad M KnaapenRoel P F Schins
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Dec 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shigeru KawakamiMitsuru Hashida
Jun 15, 2007·Free Radical Biology & Medicine·Maret G Traber, Jeffrey Atkinson
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Shigeo HisamoriYoshiharu Sakai
Oct 31, 2009·Toxicology and Applied Pharmacology·Maqusood AhamedJohn J Rowe
Nov 6, 2009·Cancer Research·Benedicte TrouillerRobert H Schiestl
Feb 16, 2010·The Science of the Total Environment·Ki Tae KimSang D Kim
Dec 1, 2007·Biointerphases·Cristina BuzeaKevin Robbie
Apr 28, 2010·Biological Trace Element Research·Jue WangFashui Hong
Dec 3, 2010·Journal of Nanoscience and Nanotechnology·Chengbin XueHuibi Xu
Jan 13, 2011·International Journal of Occupational and Environmental Health·Christiane LorenzKonrad Hungerbühler
Nov 26, 2011·Toxicology and Applied Pharmacology·Kristen SandersWilliam K Boyes
Jan 21, 2012·Environmental Science & Technology·Alex WeirNatalie von Goetz
Jan 26, 2012·Journal of Biomedical Materials Research. Part a·Xuezi SangFashui Hong
Mar 8, 2012·Apoptosis : an International Journal on Programmed Cell Death·Vyom SharmaAlok Dhawan
Apr 25, 2012·Journal of Biomedical Materials Research. Part a·Qingqing SunFashui Hong
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
May 15, 2013·Trends in Pharmacological Sciences·Takafumi SuzukiMasayuki Yamamoto
Aug 24, 2013·Journal of Agricultural and Food Chemistry·Suxin GuiFashui Hong
Sep 13, 2013·BioMed Research International·Amruta MankeYon Rojanasakul
Mar 29, 2014·Journal of Food and Drug Analysis·Tao ChenYan Li
Jun 17, 2014·Journal of Agricultural and Food Chemistry·Ruud J B PetersHans Bouwmeester
Jul 13, 2014·Chemico-biological Interactions·Mahmoud OrazizadehLayasadat Khorsandi
Apr 22, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Samy A AbdelazimMai O Kadry
Nov 11, 2015·Journal of Translational Medicine·Ling ZhouMing-Jun Wang
Feb 13, 2016·Nanotechnology·Jie Hong, Yu-Qing Zhang
Mar 30, 2018·International Journal of Nanomedicine·Shivendu RanjanAshtosh Kumar
Apr 7, 2019·Environmental Toxicology and Pharmacology·Mohamed M Abdel-DaimAhmed M Hassan
May 13, 2019·Environmental Science and Pollution Research International·Nuzhat ZahinMohamed M Abdel-Daim
Jul 10, 2019·Environmental Science and Pollution Research International·Mohamed A KandeilMohamed M Abdel-Daim
Feb 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang DuJie Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.