The protective impact of betaine on the tissue structure and renal function in isoproterenol-induced myocardial infarction in rat

Molecular Genetics & Genomic Medicine
Mohammad Maram GhartavolMohammad Hassan Khadem Ansari

Abstract

Myocardial infarction is one of the most common life threatening diseases that may lead to renal disorders via oxidative stress and inflammation. Betaine is a safe and well-tolerated compound exhibiting beneficial antioxidant and anti-inflammatory properties. Previous studies have demonstrated protective effects of betaine against myocardial infarction and renal injury. This study aimed to investigate the protective effect of betaine on tissue structure and renal function after isoprenaline-induced myocardial infarction in rats. Fifty Wistar strain male albino rats, weighing 200 ± 10, were selected for the study. The animals were housed individually under standard environmental conditions (Light-dark cycle, temperature and constant humidity) for 1 week. After acclimatization, they were randomly divided into five groups. G1, G2, and G3 groups received betaine at doses of 50, 150, and 250 mg/kg body weight/day via gavage for a period of 60 days. After 60 days, isoprenaline is injected subcutaneously (200 mg/kg body weight). In the isoprenaline group (G4), the rats were injected with isoprenaline (200 mg/kg body weight) and the control group (G5) received a standard diet (Without isoprenaline). Then, isoproterenol solution was use...Continue Reading

References

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Citations

Aug 25, 2020·Molecular Biology Reports·Anahita PourmehdiOmid Dezfoulian
Sep 11, 2020·Biological Trace Element Research·Hadi KarimkhaniGüngör Kanbak
Feb 15, 2021·International Immunopharmacology·Zheng WuJinghua Liu
May 19, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammed Al Za'abiBadreldin H Ali

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Methods Mentioned

BETA
ELISA

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