PMID: 7070835Mar 1, 1982Paper

The protective role of acquired host antigens during schistosome maturation

Parasite Immunology
D J McLaren, R J Terry

Abstract

Schistosomes grown in mice were tested at different stages of development for susceptibility to an in vitro cytotoxic effector mechanism involving eosinophils and an antibody directed against mouse determinants. Despite the fact that 5-day lung worms and 6-week adult worms both bound the antibody to their surfaces, eosinophils attached preferentially to the adults and killed them. Complement had an enhancing effect in this system. Those eosinophils which did adhere to the lung worms degranulated onto the tegument but were unable to mediate damage or killing, even when complement was activated at the parasite surface. The resistance shown by the lung worms was shared by 2-week worms and small 3-week worms. Larger 3-week worms and older stages were, however, susceptible to cell-mediated cytotoxicity in this system. We suggest that the host antigen disguise constitutes the major protective mechanism utilized by older schistosomes to evade immunity, but that the younger stages have an additional and equally effective mechanism of resistance.

References

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Citations

Feb 15, 1991·Experientia·R J Terry
Apr 1, 1988·Experimental Parasitology·D AbrahamM Mika-Grieve
Feb 1, 1987·International Journal for Parasitology·S R Smithers
Oct 1, 1983·Molecular and Biochemical Parasitology·S M RobertsR A Wilson
Feb 1, 1984·Molecular and Biochemical Parasitology·K P ForsythG F Mitchell
Mar 1, 1984·Molecular and Biochemical Parasitology·M Philipp, F D Rumjaneck
Nov 1, 1986·Molecular and Biochemical Parasitology·J F ParraT A Mota-Santos
Sep 1, 1987·Molecular and Biochemical Parasitology·N SaundersPatricia S Coulson
Jan 15, 1987·Molecular and Biochemical Parasitology·M V Rogers, D J McLaren
Sep 1, 1988·Parasitology Today·M Denis, K Chadee
Aug 1, 1984·Parasitology·D J McLaren
Mar 21, 2009·Molecular & Cellular Proteomics : MCP·Feng LiuZe-Guang Han
Jul 1, 1993·Kidney International·R S Barsoum
Apr 29, 2011·Molecular and Biochemical Parasitology·Hatem TallimaRashika El Ridi
Sep 1, 2009·Trends in Parasitology·R A Wilson, Patricia S Coulson
Mar 29, 2014·Parasite Immunology·Stephen A RedpathG Perona-Wright
Oct 1, 1986·Experimental Parasitology·A Ruppel, D J McLaren
May 1, 1986·Journal of Clinical Periodontology·L A ChristerssonR J Genco
Jan 1, 1996·Psychology & Health·J Rodriguez-MarinM A Pastor
May 7, 2020·PLoS Neglected Tropical Diseases·Arporn WangwiwatsinMatthew Berriman

Related Concepts

Metazoa
Antigen-Antibody Reactions
Antigens
Cell Adhesion
Complement Activation
Immunologic Tumoricidal Activities
Eosinophil
Schistosoma mansoni
Rats, Laboratory

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