The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Weihong LiuJianfang Yang

Abstract

Colorectal cancer (CRC) is one of the most common malignancies with high morbidity and mortality rates worldwide. This study aimed to investigate whether miR-3666 was involved in inhibitory effects of all-transretinoic acid (ATRA) on the development of colorectal cancer (CRC). Surgical specimens of CRC tissues and adjacent non-tumor mucosa were collected for determining miR-3666 expression. Human CRC HCT116 cells were treated with different doses of ATRA (10, 20, 40, and 60 μM, respectively) and/or transfected with miR-3666 mimic, miR-3666 inhibitor, E2F7 siRNAs or their controls, respectively. After different treatments, cell viability, apoptosis, migration and invasion were detected. The regulatory relationship between miR-3666 and E2F7 was investigated. Furthermore, the association between MAPK/ERK pathway and ATRA or miR-3666/E2F7 was explored. The miR-3666 was lowly expressed in CRC tissues, while E2F7 was highly expressed. ATRA decreased HCT116 cell viability, migration, and invasion, and induced apoptosis, indicating that ATRA inhibited the malignant behaviors of HCT116 cells. Moreover, ATRA increased miR-3666 expression, and effects of ATRA on the malignant behaviors of HCT116 cells were achieved by positive regulating ...Continue Reading

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Citations

Nov 28, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Linqing PanRanran Tang
Aug 14, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi LiuWenling Zhang
Jun 28, 2020·Journal of Clinical Laboratory Analysis·Cui Xu, Xiangxiu Qi
May 30, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J TanY Xu
Oct 22, 2020·Critical Reviews in Food Science and Nutrition·Ankita KumariRajeev Kapila
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Hiroki YoshiokaJunichi Iwata
Dec 29, 2020·Cancer Biomarkers : Section a of Disease Markers·Huiping TanXiangbing Jiang
Aug 7, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Smriti MittalSaroj Ghaskadbi
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Hiroki YoshiokaJunichi Iwata
Jul 20, 2021·Cancer Management and Research·ZhaoHui XuXin Chen
Jul 7, 2021·Journal of Microbiology and Biotechnology·Yuhong MaXiaofei Li

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