The protective role of ascorbic acid on hippocampal CA1 pyramidal neurons in a rat model of maternal lead exposure

Journal of Chemical Neuroanatomy
Hamid Sepehri, Farzaneh Ganji

Abstract

Oxidative stress is a major pathogenic mechanism of lead neurotoxicity. The antioxidant ascorbic acid protects hippocampal pyramidal neurons against cell death during congenital lead exposure; however, critical functions like synaptic transmission, integration, and plasticity depend on preservation of dendritic and somal morphology. This study was designed to examine if ascorbic acid also protects neuronal morphology during developmental lead exposure. Timed pregnant rats were divided into four treatment groups: (1) control, (2) 100mg/kg ascorbic acid once a day via gavage, (3) 0.05% lead acetate in drinking water, and (4) 0.05% lead+100mg/kg oral ascorbic acid. Brains of eight male pups (P25) per treatment group were processed for Golgi staining. Changes in hippocampal CA1 pyramidal neurons' somal size were estimated by cross-sectional area and changes in dendritic arborization by Sholl's analysis. One-way ANOVA was used to compare results among treatment groups. Lead-exposed pups exhibited a significant decrease in somal size compared to controls (P<0.01) that was reversed by cotreatment with ascorbic acid. Sholl's analysis revealed a significant increase in apical dendritic branch points near cell body (P<0.05) and a decreas...Continue Reading

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Citations

Sep 7, 2019·Anatomia, histologia, embryologia·Muhammet Lütfi Selçuk, Saadettin Tıpırdamaz
Sep 8, 2019·Journal of Histotechnology·Hamid A SalehAbdel Halim Deifalla
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Apr 13, 2019·Mechanisms of Ageing and Development·Yini LiangYingcai Niu
Sep 9, 2021·Nutritional Neuroscience·Morgana Moretti, Ana Lúcia S Rodrigues

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