The protective role of curcumin on testicular tissue after hindlimb ischemia reperfusion in rats

International Urology and Nephrology
Mohammad Ashrafzadeh TakhtfooladiSamaneh Shabani

Abstract

The aim of this study was to investigate the role of curcumin in remote testicular injury caused by hindlimb ischemia reperfusion (IR). Forty male Wistar rats were allocated to four groups: sham (G1), sham + curcumin (G2), IR (G3) and IR + curcumin (G4). Curcumin 200 mg/kg was administered intraperitoneally 2 h prior to IR induction. Lower extremities were subjected to IR induced by infrarenal aortic occlusion for 2 h, followed by 6 h of reperfusion. The rats were euthanized and the testes were removed. Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) and myeloperoxidase (MPO) activities and histopathological damage scores were determined in right testicular tissues. Left testes were used for wet/dry weight ratio measurement. Activities of SOD and CAT in testicular tissues were significantly decreased by IR, but curcumin pretreatment increased these levels (P < 0.05). MPO activity in testicular tissues in the G3 was significantly higher than in the G4 (P < 0.05). Significantly increased MDA levels in testicular tissues by IR were decreased by curcumin pretreatment (P < 0.05). Testis tissues showed a significant increase in GPx activity compared to the IR group when curcumin was app...Continue Reading

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Citations

Apr 1, 2016·International Urology and Nephrology·Ali Kagan Coskun, Yalcin Basaran
Sep 7, 2016·Journal of Pediatric Urology·Ahmad AsghariPejman Mortazavi
Jun 30, 2016·Acta Cirúrgica Brasileira·Ahmad AsghariPejman Mortazavi
Nov 1, 2017·Cell Stress & Chaperones·Naeimeh Shamsi-GamchiMehdi Behfar
Jan 4, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sevda Tanrıkulu-KüçükYıldız Öner-İyidoğan
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel

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