The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury

Transplant International : Official Journal of the European Society for Organ Transplantation
Haifeng GuXueying Lv

Abstract

IL-18, a proinflammatory cytokine, is produced by macrophages, epithelial cells, T cells, neutrophils, NK-T cells, and B cells, and has been implicated in the pathophysiology of a variety of inflammatory diseases including ischemia/reperfusion (IR) injury, transplant rejection, and autoimmune disease. Recent study indicated that neutralization of IL-18 with anti-IL-18 antibody or IL-18-binding protein (IL-18BP) ameliorates IR-induced myocardial injury. However, the mechanism needs to be further investigated. In our current study, syngeneic heterotopic heart transplantation was performed by a modified non-suture cuff technique. We found that IL-18BP treatment ameliorated cardiomyocyte necrosis and infiltration of CD4(+) T cells, neutrophils, and macrophages. IL-18BP-treated mice exhibited decreased expression of inflammatory cytokines including IL-1β, IL-23, IL-18, and IL-17. IL-18BP treatment suppressed Th17 differentiation in vivo and in vitro. Adoptive transfer of T cells from IL-18BP-treated mice showed alleviated cardiac IR injury when compared with that transferred from control mice. Furthermore, the decreased infiltration of mononuclear cells and production of troponin T (TnT) induced by IL-18BP treatment were both abroga...Continue Reading

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Citations

Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Letteria MinutoliDomenica Altavilla
Nov 17, 2017·Nature Reviews. Cardiology·Stefano Toldo, Antonio Abbate
Sep 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Stefano ToldoAntonio Abbate
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Sep 1, 2018·Frontiers in Immunology·Perrine BortolottiEric Kipnis
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
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Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hua LiangQiong Huang

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