The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: Expression of Hsps and inflammation-related genes and modulation of elements homeostasis

Ecotoxicology and Environmental Safety
Runxiang ZhangJun Bao

Abstract

The purpose of this study was to examine the potential role of high selenium (Se) diets in alleviating chronic cadmium (Cd) hepatic toxicity in laying hens. In the present study, 128 healthy 31-week-old laying hens were fed a diet supplemented with Se (Na2SeO3, 2 mg/kg), Cd (CdCl2, 150 mg/kg), or both Se and Cd (150 mg/kg of CdCl2 and 2 mg/kg of Na2SeO3) for 90 days. The expression levels of heat shock proteins (Hsps, including Hsp60, Hsp70 and Hsp90) and inflammation-related factors, including nuclear factor-kappa B p50 (NF-κB), cyclooxygenase-2 (COX-2), prostaglandin E synthases (PTGES), interleukin 1-beta (IL-1β), and tumor necrosis factor-α (TNF-α) were investigated. The concentrations of 28 elements were also determined. The results indicated that Cd treatment significantly increased the mRNA and protein expression levels of Hsps and significantly improved the expression of inflammation-related genes. Moreover, Cd addition to the diets resulted in disturbances in the systemic balance of 13 elements, leading to decrease in the concentrations of Cr, Mn, Sr, Ba, and Hg and increase in Li, B, Ca, Ti, Fe, Cu, Mo, and Cd concentrations. Treatment with Se significantly alleviated Cd-induced hepatic toxicity, as evidenced by a red...Continue Reading

Citations

Jun 16, 2019·Environmental Science and Pollution Research International·Kou-Kou TangRui-Feng Fan
Dec 22, 2019·Environmental Science and Pollution Research International·Xianbin WangAhmed E Abdel Moneim
Jun 13, 2020·Environmental Science and Pollution Research International·Can TaoNiya Zhang
Oct 27, 2020·Environmental Science and Pollution Research International·He HuangXiaohua Teng
Jan 7, 2021·Biological Trace Element Research·Indrajit Kar, Amlan Kumar Patra
Oct 11, 2020·Life Sciences·Gülname Fındık GüvendiYasemen Adalı
Feb 3, 2021·Antioxidants·Peter F SuraiMichael T Kidd
May 10, 2021·Environmental Pollution·Milton TalukderJin-Long Li

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