PMID: 8597419Dec 29, 1995Paper

The protective role of the hypothalamic-pituitary-adrenal axis against lethality produced by immune, infectious, and inflammatory stress

Annals of the New York Academy of Sciences
L P KapcalaR L Eskay

Abstract

We have shown that ADX and HYPOX rats exhibit a markedly increased sensitivity to the lethal effects of IL-1-beta and LPS compared to sham controls with an intact HPAA. These results indicated that the reports of lethal effects of cytokines and LPS which generates cytokines in mice with a compromised HPAA were not idiosyncratic or specific to mice but represented a general response that would have been expected in any organism with a compromised HPAA. We further demonstrated that protection against lethal effects due to IL-1-beta or LPS could be produced by treating ADX rats with glucocorticoid in a quantity estimated to be equivalent to corticosterone secretion provoked during stress. In contrast, we found that acutely stalk-sectioned rats with pituitaries disconnected from hypothalamic regulation did not show a markedly increased susceptibility to lethal effects of LPS as did ADX or HYPOX rats. Although a minority of stalk-sectioned rats were killed by LPS, the majority of rats were protected from lethal actions of LPS. This response suggested that an intact pituitary-adrenal axis without the normal hypothalamic control could still provide significant protection presumably due to generation of cytokines which stimulated the p...Continue Reading

References

Dec 1, 1992·Archives of Surgery·M P Lilly, D S Gann
Sep 1, 1992·The Journal of Endocrinology·M S Harbuz, S L Lightman
Nov 15, 1992·Annals of Internal Medicine·E M SternbergP W Gold
Jan 1, 1992·Chemical Immunology·C A Dinarello
Jan 1, 1991·Annals of the New York Academy of Sciences·J DonnererF Lembeck
Mar 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G WakabayashiC A Dinarello
Jan 1, 1991·Brain Research. Molecular Brain Research·G A Higgins, J A Olschowka
Jan 1, 1990·The American Review of Respiratory Disease·S MasuyamaT Kuriyama
Apr 23, 1990·Brain Research·R M LechanS Reichlin
Dec 1, 1989·British Journal of Pharmacology·M PerrettiL Parente
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E M SternbergR L Wilder
Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S W LeeA C Allison
May 1, 1988·The Journal of Experimental Medicine·R BertiniP Ghezzi
Apr 19, 1988·Brain Research·F CoceaniC A Dinarello
Nov 1, 1985·The American Journal of Physiology·J AhnM Field
Feb 1, 1985·Journal of Leukocyte Biology·M J Staruch, D D Wood
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·C SzabóJ R Vane
May 18, 1995·The New England Journal of Medicine·G P Chrousos

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Citations

Mar 1, 2003·Journal of Reproductive Immunology·Mark P Hedger, Andreas Meinhardt
Nov 26, 2002·Journal of Neuroimmunology·John J HaddadBared Safieh-Garabedian
Feb 1, 1997·Journal of Neuroimmunology·K KaralisJ A Majzoub
Jan 14, 1998·Brain Research. Molecular Brain Research·J Yao, R W Johnson
Dec 14, 2002·Brain, Behavior, and Immunity·Paul H Black
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·L V BorovikovaK J Tracey
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Apr 2, 2005·Viral Immunology·Marni N SilvermanAndrew H Miller
Oct 1, 1998·Proceedings. Biological Sciences·L RåbergE Svensson
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·K E BethinL J Muglia
Oct 21, 2009·International Immunopharmacology·V Kumar, A Sharma
May 28, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·H HimmerichT Pollmächer
Mar 18, 2008·Hormones and Behavior·Takashi MatsuwakiMasugi Nishihara
Jul 19, 2015·Brain, Behavior, and Immunity·Erin GlennonKaren Bulloch
Jun 24, 2009·Journal of Neurochemistry·Kurt M LucinPhillip G Popovich
Sep 20, 2011·Acta Psychiatrica Scandinavica·Hanna JärnumElna-Marie Larsson
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Leman K MutluIngo Bechmann
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Peter RosenbergerClaudia D Spies
Jun 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Noko R MphahlelePeter R Kamerman
Aug 13, 2004·Journal of Neurobiology·Katalin M HorvathPeter Meerlo
Mar 9, 2006·Clinical and Vaccine Immunology : CVI·Christopher J PapasianDavid C Morrison

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