The protein kinase C isoforms leading to MAP-kinase activation in CHO cells

Biochemical and Biophysical Research Communications
K YamaguchiY Nishizuka

Abstract

Stimulation of CHO cells with phorbol ester caused transient activation of mitogen-activated protein kinase (MAP-kinases with 42 and 44 kDa). A similar treatment of CHO cells which overexpress a massive amount of the alpha- or delta-isoform of protein kinase C (PKC) resulted in the prolonged activation of MAP-kinase and eventually in the appearance of mostly dikaryotic, sometimes tetrakaryotic cells. The results suggest that the delta-isoform, as well as the alpha-isoform, has a potential to cause MAP kinase activation. Unusual activation of the PKC/MAP-kinase pathway, however, may lead to abnormal cytokinesis.

Citations

Mar 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P FlintP A Fisher
Dec 17, 2002·Molecular and Cellular Biology·Yoichi OhiroNobuo Horikoshi
Nov 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saminathan MuthusamyJaleh Malakooti
Oct 17, 1996·European Journal of Pharmacology·A L Ruzycky, A Kulick
May 9, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vivian SoetiknoKenichi Watanabe
Sep 30, 2010·Dose-response : a Publication of International Hormesis Society·Nicholas S LukeHisham A El-Masri
Dec 13, 2003·The Journal of Biological Chemistry·Jennifer A ClarkJennifer D Black
Sep 10, 2014·Chembiochem : a European Journal of Chemical Biology·Toni Kühl, Diana Imhof
Sep 12, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Keiichiro YoshidaHajime Sawada
Oct 13, 2006·The Journal of Biological Chemistry·Kazuyuki KitataniYusuf A Hannun
Mar 27, 1999·The Journal of Biological Chemistry·A V Graça-SouzaP L Oliveira
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A ImamU Hammerling
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M ThibonnierC L Plesnicher
Nov 24, 2020·Neurobiology of Disease·Luca MurruMaria Passafaro
Apr 1, 1996·Current Opinion in Cell Biology·S Jaken

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