The protein kinase C phosphorylation site on GAP-43 differentially regulates information storage.

Hippocampus
Matthew R Holahan, A Routtenberg

Abstract

Protein kinase C (PKC) is known to regulate phosphorylation of substrates such as MARCKS, GAP-43, and the NMDA receptor, all of which have been linked to synaptic plasticity underlying information storage processes. Here we report on three transgenic mice isoforms differentiated both by mutation of the PKC site on GAP-43 as well as by their performance in three learning situations: (1) a radial arm maze task, which evaluates spatial memory and its retention, (2) fear conditioning which assesses contextual memory, and (3) the water maze which also evaluates spatial memory and its retention. The present results show, for the first time to our knowledge, that the phosphorylation state of a single site on an identified brain growth- and plasticity-associated protein differentially regulates performance of three different memory-associated tasks.

References

Jul 1, 1989·Brain Research. Brain Research Reviews·D J Linden, A Routtenberg
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·A RouttenbergU Namgung
Oct 23, 2003·The Biochemical Journal·Seng-Lai Tan, Peter J Parker
Sep 25, 2004·Hippocampus·Jerome L RekartAryeh Routtenberg
Jan 1, 2005·Trends in Neurosciences·Aryeh Routtenberg, Jerome L Rekart
Apr 4, 2007·Learning & Memory·Wayne S Sossin
Jun 8, 2007·Learning & Memory·Matthew R HolahanAryeh Routtenberg
Dec 29, 2007·Neurobiology of Learning and Memory·Aryeh Routtenberg

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Citations

Jun 26, 2012·Psychiatry and Clinical Neurosciences·Guillaume FondDelphine Capdevielle
Dec 15, 2015·Molecular Biology of the Cell·Kathryn R WilliamsGary J Bassell
Aug 6, 2013·Behavioural Brain Research·Styliani ZisopoulouDimitra Mangoura
Feb 23, 2019·International Journal of Immunopathology and Pharmacology·Sergio CaputiVladimir Khavinson
Aug 21, 2012·Learning & Memory·Karsten Baumgärtel, Isabelle M Mansuy

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