PMID: 8957003Dec 1, 1996Paper

The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing

Genes & Development
Z F WangWilliam F Marzluff

Abstract

Replication-dependent histone mRNAs are not polyadenylated but end in a conserved 26-nucleotide structure that contains a stem-loop. Much of the cell cycle regulation of histone mRNA is post-transcriptional and is mediated by the 3' end of histone mRNA. The stem-loop binding protein (SLBP) that binds the 3' end of histone mRNA is a candidate for the factor that participates in most, if not all, of the post-transcriptional regulatory events. We have cloned the cDNA for the SLBP from humans, mice, and frogs, using the recently developed yeast three-hybrid system. The human SLBP is a 31-kD protein and contains a novel RNA-binding domain, which has been mapped to a 73-amino-acid region of the protein. The cloned SLBP is the protein bound to the 3' end of histone mRNA as antibodies specific for the SLBP remove all specific binding activity from nuclear and polyribosomal extracts. These depleted extracts do not cleave histone pre-mRNA efficiently, demonstrating that the SLBP is required for efficient histone pre-mRNA processing.

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Citations

Mar 21, 1998·Developmental Genetics·H J ClarkeO A Mohamed
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Bellini
May 15, 2003·Biochemical and Biophysical Research Communications·Natalia DolzhanskayaRobert B Denman
Jul 10, 1998·Molecular and Biochemical Parasitology·C MarañónM C López
Nov 26, 1999·Gene·Z Dominski, W F Marzluff
Mar 21, 1998·Current Opinion in Biotechnology·R M Frederickson
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·David S BernsteinMarvin Wickens
Feb 18, 1999·Current Opinion in Chemical Biology·B L Drees
Oct 18, 2008·Nature Reviews. Genetics·William F MarzluffRobert J Duronio
Oct 5, 2010·Nature Structural & Molecular Biology·Roderick J O'SullivanJan Karlseder
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Prachi N GhuleGary S Stein
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takashi IdeueTetsuro Hirose
Jun 12, 2002·Molecular Biology of the Cell·Michael L WhitfieldDavid Botstein
Apr 15, 2005·Molecular Biology of the Cell·Judith A ErkmannWilliam F Marzluff
Sep 11, 2004·Nucleic Acids Research·Michael L WhitfieldWilliam F Marzluff
Jun 28, 2013·Nucleic Acids Research·Holger von MoellerElena Conti

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