The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.

Proceedings of the National Academy of Sciences of the United States of America
Samuel Bouyain, Dara J Watkins

Abstract

The receptor protein tyrosine phosphatases gamma (PTPRG) and zeta (PTPRZ) are expressed primarily in the nervous system and mediate cell adhesion and signaling events during development. We report here the crystal structures of the carbonic anhydrase-like domains of PTPRZ and PTPRG and show that these domains interact directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules. Interestingly, these receptors exhibit distinct specificities: PTPRZ binds only to CNTN1, whereas PTPRG interacts with CNTN3, 4, 5, and 6. Furthermore, we present crystal structures of the four N-terminal immunoglobulin repeats of mouse CNTN4 both alone and in complex with the carbonic anhydrase-like domain of mouse PTPRG. In these structures, the N-terminal region of CNTN4 adopts a horseshoe-like conformation found also in CNTN2 and most likely in all CNTNs. This restrained conformation of the second and third immunoglobulin domains creates a binding site that is conserved among CNTN3, 4, 5, and 6. This site contacts a discrete region of PTPRG composed primarily of an extended beta-hairpin loop found in both PTPRG and PTPRZ. Overall, these findings implicate PTPRG, PTPRZ and CNT...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N X Krueger, H Saito
Jul 1, 1994·Biopolymers·R NorelR Nussinov
Dec 20, 1993·Journal of Molecular Biology·M C Lawrence, P M Colman
Feb 2, 1999·Journal of Molecular Biology·L Lo ConteJ Janin
Sep 26, 2000·Molecular and Cellular Biology·S HarrochJ Schlessinger
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A WhittingtonD W Christianson
Oct 5, 2001·Molecular and Cellular Biology·J N AndersenN P Møller
Nov 7, 2001·The Journal of Biological Chemistry·B C TrippJ G Ferry
Oct 24, 2002·Acta Crystallographica. Section D, Biological Crystallography·Paul D AdamsThomas C Terwilliger
Dec 31, 2002·Physiological Reviews·Karl G Johnson, David Van Vactor
Jan 31, 2003·Proteins·Simon C LovellDavid C Richardson
Mar 26, 2003·The European Journal of Neuroscience·Hong LiKazutada Watanabe
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Jan 6, 2007·Science·Ivan A YudushkinPhilippe I H Bastiaens
Aug 28, 2007·Nature·Rob MeijersDietmar Schmucker
Sep 4, 2007·Protein Science : a Publication of the Protein Society·Mario MörtlWolfram Welte
Mar 28, 2008·Neuron·Tomomi Kaneko-GotoYoshihiro Yoshihara
Sep 27, 2008·Bioinformatics·L HolmA Schenkel
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

❮ Previous
Next ❯

Citations

Mar 30, 2011·Journal of Molecular Modeling·Karolina MikulskaWiesław Nowak
Sep 10, 2010·The New England Journal of Medicine·Keith H BaratzAlbert O Edwards
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Smaragda LamprianouSheila Harroch
Jul 17, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Irene HinterseherHelena Kuivaniemi
Apr 3, 2012·The Journal of Clinical Investigation·Michael L Dustin
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Crystal R McClainSteven A Goldman
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Albert I ChenLouis F Reichardt
Aug 19, 2011·International Journal of Biological Sciences·Irene M ChesiniWiljan J A J Hendriks
Jan 12, 2012·TheScientificWorldJournal·Ludwig T WeckbachBarbara Walzog
Feb 4, 2016·Journal of the American Society of Nephrology : JASN·Yuehan ZhouWalter F Boron
Apr 24, 2015·Computational and Structural Biotechnology Journal·Thomas SciorEduardo M Salinas-Stefanon
May 26, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marie-Hélène DizierFlavie Mathieu
Jun 12, 2012·The FEBS Journal·Alma N MohebianySheila Harroch
Feb 11, 2011·Autism Research : Official Journal of the International Society for Autism Research·Catherine E CottrellGail E Herman
Sep 4, 2012·The FEBS Journal·Wiljan J A J HendriksJeroen den Hertog
Sep 23, 2014·Seminars in Cell & Developmental Biology·Andrew W Stoker
May 31, 2011·Journal of Molecular Biology·Jasmina S RedzicElan Zohar Eisenmesser
Jul 13, 2011·Developmental Biology·Rupalatha MaddalaPonugoti V Rao
Dec 4, 2010·Biochimica Et Biophysica Acta·Catherine A BoucherRichard N Sandford
Aug 18, 2010·Communicative & Integrative Biology·Samuel Bouyain, Dara J Watkins
Jul 17, 2012·Cell Adhesion & Migration·Roman M NikolaienkoSamuel Bouyain
Aug 2, 2011·Biochimica Et Biophysica Acta·Meghan E McDevitt, Lisa A Lambert
Jul 23, 2013·European Journal of Pharmacology·Amila ZukoJ Peter H Burbach
Sep 23, 2014·Seminars in Cell & Developmental Biology·Charlotte H ColesA Radu Aricescu
Sep 20, 2016·ELife·Kerry M GoodmanLawrence Shapiro
Feb 18, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Feb 6, 2014·The Journal of Biological Chemistry·Marilyne LabasqueCatherine Faivre-Sarrailh
Jan 21, 2020·Clinical Genetics·Kevin D Mangum, Mark A Farber
Jan 22, 2020·Human Molecular Genetics·Xabier Elorza-VidalRaúl Estévez
Jun 3, 2020·The FEBS Journal·Veronika ReitererHesso Farhan
Nov 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordan L WoehlBrian V Geisbrecht
Sep 12, 2015·World Journal of Gastroenterology : WJG·De-Hu ChenBo-Jian Jiang
Dec 27, 2016·Frontiers in Molecular Neuroscience·Amila ZukoJ P H Burbach
Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Fredrik H SterkyThomas C Südhof
Apr 10, 2017·Genome Biology and Evolution·Amy M BoddyDerek E Wildman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.