The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Fiona C KimberleyJ P Medema

Abstract

A proliferation-inducing ligand (APRIL) (also known as TALL-2 and TRDL-1) is a member of the tumor necrosis factor (TNF) superfamily that has tumorigenic properties but is also important for the induction of humoral immune responses. APRIL binds two TNF receptors: transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA) as well as heparan sulfate proteoglycans (HSPGs). The aim of this study was to clarify the role of the HSPG interaction in canonical APRIL signaling, because it has been proposed to act as a docking site and also to play a role in direct signaling. In this study, we generated point mutants of soluble APRIL that lack either the capacity to bind HSPGs or TACI and BCMA and then tested the function of these mutants in mouse B-cell assays. In contrast to previous reports, we found that APRIL alone is sufficient to costimulate B-cell proliferation and drive IgA production and does not require artificial antibody cross-linking. We found no evidence that APRIL requires signaling through HSPGs but, notably, were able to show that binding of APRIL to HSPGs is crucial for mediating natural APRIL cross-linking to allow for optimal activation of murine B cells.

References

Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M GrellP Scheurich
May 19, 1998·Trends in Biochemical Sciences·D G Myszka, T A Morton
Sep 22, 1998·The Journal of Experimental Medicine·M HahneJ Tschopp
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin L HsuMichael P Cancro
Aug 3, 2002·Nature Immunology·Mikhail B LitinskiyAndrea Cerutti
May 2, 2003·Nature·Yingfang LiuGongyi Zhang
Oct 14, 2003·Biochemical Pharmacology·Geertruida M KolfschotenJan Paul Medema
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing HeAndrea Cerutti
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonid GorelikSusan L Kalled
Jan 7, 2004·The Journal of Experimental Medicine·Brian P O'ConnorRandolph J Noelle
Jan 20, 2004·Molecular and Cellular Biology·Eugene VarfolomeevAvi Ashkenazi
Feb 7, 2004·The Journal of Biological Chemistry·Darshana R PatelRobert F Kelley
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing HeAndrea Cerutti
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emanuela CastigliRaif S Geha
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lai Guan NgCharles R Mackay
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Svetlana Shulga-MorskayaMartin L Scott
Sep 29, 2004·Journal of Molecular Biology·Heidi J A WallweberSarah G Hymowitz
Nov 16, 2004·The Journal of Biological Chemistry·Sarah G HymowitzMelissa A Starovasnik
Jan 5, 2005·The Journal of Experimental Medicine·Emanuela CastigliRaif S Geha
Apr 23, 2005·Cell Death and Differentiation·J HendriksJ P Medema
Apr 27, 2005·The Journal of Experimental Medicine·Karine IngoldPascal Schneider
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min YangAdrian T Ting
Dec 17, 2005·Blood·Daniela BischofRichard J Bram
Nov 23, 2006·Blood·Daisuke SakuraiTetsuji Kobata
Sep 28, 2007·European Journal of Immunology·Gijs HardenbergJan Paul Medema
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Micah J BensonRandolph J Noelle
Mar 26, 2008·Immunology and Cell Biology·Gijs HardenbergJan Paul Medema

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Citations

Jun 19, 2012·Cell Death and Differentiation·V LascanoM Hahne
Oct 5, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matthias A NeusserClemens D Cohen
Sep 11, 2012·The Journal of Biological Chemistry·Fiona C KimberleyJan Paul Medema
Nov 28, 2012·Annals of the Rheumatic Diseases·Leticia FernandezMichael Hahne
May 27, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Feng WangHuimin Wang
Feb 12, 2014·Immunology Letters·Vishal J SindhavaMichael P Cancro
Feb 11, 2014·Cytokine & Growth Factor Reviews·Radhika GoenkaMichael P Cancro
Jan 15, 2014·Cytokine & Growth Factor Reviews·Maogen ChenSong Guo Zheng
Nov 28, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Meng LianFan Yang
Jul 6, 2014·Seminars in Immunology·William A FiggettFabienne Mackay
Oct 25, 2011·Immunological Reviews·Robert C RickertAna V Miletic
Aug 24, 2010·Immunological Reviews·Michael J TownsendAndrew C Chan
Dec 25, 2010·European Journal of Immunology·Yanping XiaoEckhard R Podack
Jul 20, 2010·Immunological Reviews·Raul ElguetaRandolph J Noelle
Apr 14, 2015·Journal of Immunology Research·Yi ZhangJuan Tao
Sep 24, 2014·PloS One·Gözde IsikRogier W Sanders
Mar 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shen Yun FooSimon Phipps
Sep 1, 2017·Clinical Microbiology Reviews·Jiro Sakai, Mustafa Akkoyunlu
Aug 30, 2017·Cold Spring Harbor Perspectives in Biology·David Wallach
Oct 31, 2018·Journal of Leukocyte Biology·Laura E Collins, Linda Troeberg
Jun 13, 2009·Nature Reviews. Immunology·Fabienne Mackay, Pascal Schneider
Apr 4, 2019·Journal of Cellular Physiology·Arezoo G ShabgahMojgan Mohammadi
Jul 30, 2019·British Journal of Pharmacology·Christine Kowalczyk-QuintasPascal Schneider
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·George NotasElias Castanas
Nov 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadine JarousseLaurent Coscoy
Feb 22, 2017·International Reviews of Immunology·Eileen SamyPascal Schneider
Oct 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vassilia-Ismini AlexakiElias Castanas
Oct 2, 2019·Frontiers in Immunology·Doan C NguyenF Eun-Hyung Lee
May 7, 2013·Molecular Cancer Therapeutics·Jeffery S SwersManuel Baca
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Kirstin Kucka, Harald Wajant
Jul 27, 2021·Frontiers in Oncology·Alessandra RomanoNicola Giuliani
Aug 28, 2021·Cytokine & Growth Factor Reviews·Kinga Henryka Nowacka, Ewa Jabłońska

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