The Proteome of Cataract Markers: Focus on Crystallins

Advances in Clinical Chemistry
Keke ZhangYi Lu

Abstract

Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Several PTMs have been described in proteins isolated from relatively old human lenses, including phosphorylation, deamidation, racemization, truncation, acetylation, and methylation. An overwhelming majority of previous cataract proteomic studies have exclusively focused on crystallin proteins, which are the most abundant proteome components of the lens. To investigate the proteome of cataract markers, this chapter focuses on the proteomic research on the functional relevance of the major PTMs in crystallins of human cataractous lenses. Elucidating the role of these modifications in cataract formation has been a challenging task because they are among the most difficult PTMs to study analytically. The proteomic status of some amides presents similar properties in normal aged and cataractous lenses, whereas some may undergo greater PTMs in cataract. Therefore, it is of great importance to review the current proteomic research on crystallins, the major protein markers in different types of cataract...Continue Reading

Citations

Jul 23, 2020·Protein Science : a Publication of the Protein Society·Calvin J VetterKirsten J Lampi
Apr 30, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Weiwei GaoRuihua Lin
Aug 23, 2020·International Journal of Molecular Sciences·Viviana M BerthoudEric C Beyer
Jan 6, 2021·Neurotoxicity Research·Chongyi LiJian Ye
Feb 19, 2021·Journal of Cellular and Molecular Medicine·Aihua LiuLijie Dong
Aug 27, 2021·Frontiers in Genetics·Hongli Zhu, Zhichang Zhang

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