The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

Chemico-biological Interactions
Federico BuonannoClaudio Ortenzi

Abstract

Climacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to the group of resorcinolic lipids, compounds that show antimicrobial, antiparasitic and antitumor activities. We investigated the cytotoxic activity of the chemically synthesized toxin on: (1) human tumor squamous carcinoma A431 cells, (2) human promyelocytic leukaemia HL60 cells, and (3) human non-tumor endothelial EA.hy926 cells. The results showed that climacostol effectively inhibited the growth of tumor cell lines in a dose-dependent manner by inducing programmed cell death, with non-tumor cells proving significantly more resistant to the toxin.

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Citations

May 2, 2013·Apoptosis : an International Journal on Programmed Cell Death·Laura BonfiliAnna Maria Eleuteri
Mar 10, 2010·Cellular and Molecular Life Sciences : CMLS·Maria Stasiuk, A Kozubek
Feb 12, 2014·The Journal of Eukaryotic Microbiology·Federico BuonannoClaudio Ortenzi
Sep 17, 2015·Journal of Basic Microbiology·Federico Buonanno, Claudio Ortenzi
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elisabetta CatalaniDavide Cervia
May 31, 2020·Microorganisms·Federico BuonannoClaudio Ortenzi
May 6, 2014·Journal of Medicinal Chemistry·Riccardo PettinariAnna Maria Eleuteri

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