The provisional matrix: setting the stage for tissue repair outcomes

Matrix Biology : Journal of the International Society for Matrix Biology
Thomas H Barker, Adam J Engler

Abstract

Since its conceptualization in the 1980s, the provisional matrix has often been characterized as a simple fibrin-containing scaffold for wound healing that supports the nascent blood clot and is functionally distinct from the basement membrane. However subsequent advances have shown that this matrix is far from passive, with distinct compositional differences as the wound matures, and providing an active role for wound remodeling. Here we review the stages of this matrix, provide an update on the state of our understanding of provisional matrix, and present some of the outstanding issues related to the provisional matrix, its components, and their assembly and use in vivo.

References

Aug 8, 1998·Trends in Cell Biology·A Woods, J R Couchman
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M K Magnusson, D F Mosher
Aug 10, 2010·Annual Review of Cell and Developmental Biology·Purva SinghJean E Schwarzbauer
Aug 3, 2011·Biochemistry·Galina TsurupaLeonid Medved
Oct 24, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Brant HubbardMichael L Smith
May 12, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Boris Hinz

❮ Previous
Next ❯

Citations

Dec 24, 2017·Scientific Reports·Christopher A Lemmon, Seth H Weinberg
Jul 12, 2018·Molecular Biology of the Cell·Si-Hyoung ParkKwang-Min Choe
Oct 13, 2018·Physiological Genomics·Marius Catalin StaiculescuJessica E Wagenseil
Feb 16, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·A Sue MenkoMary Ann Stepp
Dec 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mackenzie E CodenSergejs Berdnikovs
Feb 9, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Samuel J GhilardiAllyson E Sgro
May 30, 2020·Journal of the American Heart Association·Mabruka AlfaidiA Wayne Orr
Jun 20, 2020·Expert Review of Proteomics·Jörn DengjelAlexander Nyström
Apr 9, 2020·The European Respiratory Journal·Clemens K ProbstRachel S Knipe
Jul 3, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Randolph StoneRobert J Christy
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
Jan 3, 2018·The Journal of Clinical Investigation·Mitsuo YamauchiJonathan M Kurie
Aug 17, 2019·Frontiers in Cardiovascular Medicine·Sinead A O'RourkeMichael G Monaghan
Jul 6, 2019·International Journal of Inflammation·Luis Cañedo-Dorantes, Mara Cañedo-Ayala
May 20, 2020·Frontiers in Oncology·Georgios EfthymiouEllen Van Obberghen-Schilling
Jan 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Horacio Maldonado, James S Hagood
Jan 10, 2021·Matrix Biology : Journal of the International Society for Matrix Biology·Kyle Sylakowski, Alan Wells
May 2, 2020·Journal of the American College of Cardiology·Nikolaos G Frangogiannis, Jason C Kovacic
Jan 21, 2021·Toxicologic Pathology·Meg Ferrell RamosSharmila Masli
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Ana Catarina SilvaDiana S Nascimento
Mar 17, 2020·Matrix Biology : Journal of the International Society for Matrix Biology·Mahbubul H ShihanMelinda K Duncan
Mar 10, 2021·Macromolecular Bioscience·Stephani StamboroskiDorothea Brüggemann
Mar 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marisa AssunçãoAnna Blocki
Jul 15, 2020·Experimental Eye Research·Edgar M Espana, David E Birk
Mar 16, 2021·Current Opinion in Oncology·Angélique Saint, Ellen Van Obberghen-Schilling
Jan 14, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Patricia RousselleCécile Garnier
May 28, 2021·Annals of the New York Academy of Sciences·Tilmann Wurtz
Apr 21, 2019·Microbiology Spectrum·Sven HammerschmidtKlaus T Preissner
Jun 18, 2021·The FEBS Journal·Donovan Correa-Gallegos, Yuval Rinkevich
Jul 3, 2021·International Journal of Molecular Sciences·Hana I Lim, Katherine A Hajjar
Jun 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Peter SobolewskiMiroslawa El Fray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Related Papers

American Journal of Hospital Pharmacy
W A Zellmer
BioMed Research International
Pawel OlczykKatarzyna Komosinska-Vassev
Journal of Toxicology. Clinical Toxicology
R I Ellin
Matrix Biology : Journal of the International Society for Matrix Biology
Patricia RousselleCécile Garnier
© 2022 Meta ULC. All rights reserved