PMID: 7545859Jan 1, 1995Paper

The proximal peripheral nervous system is a major site of demyelination in experimental autoimmune encephalomyelitis induced in the Lewis rat by a myelin basic protein-specific T cell clone

Acta Neuropathologica
M P PenderP A McCombe

Abstract

Experimental autoimmune encephalomyelitis (EAE) was induced in the Lewis rat by the passive transfer of a cytotoxic CD4+ T cell clone specific for the 72-89 peptide of guinea-pig myelin basic protein (MBP). Histological studies on rats with neurological signs showed that inflammation was present in the proximal peripheral nervous system (PNS), namely the spinal roots, as well as in the central nervous system (CNS). The main sites of demyelination were the spinal roots in the PNS, and the spinal cord root entry and exit zones in the CNS. The major involvement of the proximal PNS in autoimmune disease directed at MBP is in marked contrast to EAE induced by immunisation with myelin proteolipid protein, where the inflammation and demyelination are restricted to the CNS. These findings may have implications for the human inflammatory demyelinating diseases including multiple sclerosis, in which MBP is a putative target antigen.

References

Jul 1, 1991·Journal of the Neurological Sciences·M P PenderJ F Kerr
Feb 12, 1987·The New England Journal of Medicine·T HemachudhaP Phanuphak
Oct 1, 1986·Journal of the Neurological Sciences·M P Pender
Dec 1, 1972·Archives of Biochemistry and Biophysics·S W Brostoff, E H Eylar
Apr 1, 1973·Journal of Neurochemistry·S GreenfieldP Morell
Jan 1, 1993·Muscle & Nerve·S G Waxman

❮ Previous
Next ❯

Citations

May 16, 2009·Nature Reviews. Immunology·Joan Goverman
Jul 31, 2012·La Presse médicale·Nishath HamzaCees G M Kallenberg
Feb 16, 2018·Journal of Neuroscience Research·Ivana BjelobabaIrena Lavrnja
Apr 7, 2009·Current Protocols in Immunology·Mark MannieJolie A Stepaniak
Oct 24, 2017·Current Protocols in Neuroscience·Kalliopi PitarokoiliRalf Gold
Jan 10, 2018·Cold Spring Harbor Perspectives in Medicine·Simon Glatigny, Estelle Bettelli
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith M GreerMichael P Pender
Oct 30, 2020·Frontiers in Immunology·Monokesh K SenDavid A Mahns

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.