PMID: 8590266Jan 1, 1995Paper

The pruritogenic and inflammatory effects of prostanoids in the conjunctiva

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
D F WoodwardC S Spada

Abstract

The therapeutic utility of cyclooxygenase (CO) inhibitors, such as ketorolac, in reducing the inflammatory events associated with allergic conjunctivitis is not unexpected since prostanoids (PG) elicit conjunctival redness (PGD2, PGE2, PGF2 alpha), edema (PGD2, TxA2), eosinophil infiltration (PGD2, PGJ2) and mucous cell discharge (PGD2, PGJ2, TxA2). Recently, topically administered ketorolac has also been reported to alleviate the itching associated with allergic conjunctivitis. This was viewed as intriguing since CO inhibitors are not regarded as useful for treating itching dermatoses and PGs do not elicit itching when applied to the skin. In order to investigate the antipruritic activity of ketorolac, we developed a model for reproducibly measuring ocular surface itch responses. The model involves itch-scratch responses to pruritogens applied locally to the ocular surface. Painful and foreign body stimuli do not produce an itch-scratch response. Unlike reported skin studies, PGE2 was a potent itch-producing substances in the conjunctiva. PGD2 was weakly pruritogenic but PGF2 alpha and the TxA2-mimetic U-46619 were inactive. The PG precursor arachidonic acid was also a potent pruritogen and its effects were inhibited by ketoro...Continue Reading

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Citations

Dec 4, 2003·European Journal of Pharmacology·Ken-ichiro InoueToshikazu Yoshikawa
Oct 4, 1997·Managed Care Interface·P R WilsonD G Cave
Feb 23, 2002·Journal of Dermatological Science·M Schmelz
Sep 19, 2002·British Journal of Pharmacology·Yoshimasa TakahashiHiroichi Nagai
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Terumasa HashimotoShigekatsu Kohno
Oct 26, 2000·The British Journal of Ophthalmology·A LeonardiA G Secchi
Jan 17, 2009·Neuroscience and Biobehavioral Reviews·Martin Schmelz
Feb 20, 2008·Immunology and Allergy Clinics of North America·Leonard Bielory
Nov 22, 2005·Dermatologic Therapy·Marcello StanteTorello Lotti
Nov 10, 2011·Acta Ophthalmologica·Brett P BieloryLeonard Bielory
Sep 8, 2004·International Immunopharmacology·Kazuhisa MinamiChiaki Kamei
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Leonard BieloryTheoharis Theoharides
Nov 2, 2011·International Archives of Allergy and Immunology·Karin J StebbinsDaniel S Lorrain
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
May 9, 2002·Expert Opinion on Pharmacotherapy·Leonard Bielory
Jun 29, 2005·Anesthesiology·Beverly WaxlerSara F Rabito
Mar 4, 2003·Journal of Neurophysiology·M SchmelzH O Handwerker
Jan 25, 2003·International Ophthalmology Clinics·Mitchell H Friedlaender
Apr 28, 2009·European Journal of Ophthalmology·Vincenzo RussoNicola Delle Noci

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