The Pseudomonas aeruginosa AlgZR two-component system coordinates multiple phenotypes

Frontiers in Cellular and Infection Microbiology
Yuta OkkotsuMichael J Schurr

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes a multitude of infections. These infections can occur at almost any site in the body and are usually associated with a breach of the innate immune system. One of the prominent sites where P. aeruginosa causes chronic infections is within the lungs of cystic fibrosis patients. P. aeruginosa uses two-component systems that sense environmental changes to differentially express virulence factors that cause both acute and chronic infections. The P. aeruginosa AlgZR two component system is one of its global regulatory systems that affects the organism's fitness in a broad manner. This two-component system is absolutely required for two P. aeruginosa phenotypes: twitching motility and alginate production, indicating its importance in both chronic and acute infections. Additionally, global transcriptome analyses indicate that it regulates the expression of many different genes, including those associated with quorum sensing, type IV pili, type III secretion system, anaerobic metabolism, cyanide and rhamnolipid production. This review examines the complex AlgZR regulatory network, what is known about the structure and function of each protein, and how it relates to the orga...Continue Reading

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Citations

Mar 17, 2015·Biotechnology Advances·Vladimir JirkuJan Masak
Sep 23, 2016·Molecular Microbiology·Stuti K Desai, Linda J Kenney
May 17, 2017·FEMS Microbiology Letters·Vanessa I FrancisSteven L Porter
Jul 12, 2018·Molecular Microbiology·Yun Heacock-KangTung T Hoang
Dec 10, 2014·Journal of Bacteriology·Christopher L PritchettMichael J Schurr
May 31, 2019·Clinical Microbiology Reviews·Sankalp MalhotraDaniel J Wozniak
Sep 26, 2019·Frontiers in Cellular and Infection Microbiology·Claire L HewsTracy L Raivio
Oct 28, 2019·Frontiers in Cellular and Infection Microbiology·Shubham Chakravarty, Eric Massé
Nov 8, 2020·Applied and Environmental Microbiology·Shannon R ColemanRobert E W Hancock
Oct 21, 2020·Journal of Bacteriology·Katherine J Graham, Lori L Burrows
Jun 3, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Said M DaboorZhenyu Cheng
Mar 28, 2021·Applied and Environmental Microbiology·Benjamin X WangMichael T Laub
Jan 4, 2019·ACS Applied Materials & Interfaces·Gannon M KeheDevatha P Nair

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Methods Mentioned

BETA
environmental stress
footprinting
bronchoalveolar lavage

Software Mentioned

Phyre2
ClustalW
TMHMM
SOSUI
Raptor X

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