The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline

International Psychogeriatrics
Taisei WakeMasaru Mimura

Abstract

ABSTRACTIn Japan, 4.6 million people are living with dementia and the number is expected to rise to 7 million by 2025. Amyloid-β (Aβ) positron emission tomography (PET) is used for cognitively normal Japanese people with or without subjective cognitive decline (SCD) for the purpose of clinical trials or diagnosis. Nevertheless, no empirical studies have been conducted on the safety of disclosing amyloid status to such populations. We conducted amyloid PET imaging on 42 participants (Aβ positive (n = 10) and negative (n = 32)). State anxiety and depression were measured at pre- and post-disclosure, and test-related distress at post-disclosure. Mean state anxiety and depression scores were below the cut-off through pre- and post-disclosure in the Aβ positive and negative groups. State anxiety and depression did not change over time and were not different between groups. Mean test-related distress scores were within normal limits at post-disclosure in both groups. No significant difference was found between groups. Disclosing Aβ positive results did not cause greater mood disturbance than negative results in a short period of time. The short-term psychological safety of disclosing Aβ PET results to asymptomatic Japanese adults wit...Continue Reading

References

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Citations

Jul 19, 2018·Expert Opinion on Pharmacotherapy·Tomoyuki NagataMasaru Mimura
May 29, 2018·International Psychogeriatrics·Rory Durcan, Alan J Thomas
May 7, 2019·Alzheimer Disease and Associated Disorders·Melissa J ArmstrongC D Mullins
May 7, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Yasuyuki HonjoHajime Takechi
Feb 21, 2019·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Yasuyuki Honjo, Hajime Takechi
Jun 5, 2019·Alzheimer's Research & Therapy·Carl TaswellChristopher C Rowe
Mar 22, 2019·International Psychogeriatrics·Wei Theng SngTih-Shih Lee
Dec 29, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Kristian Steen FrederiksenGunhild Waldemar
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Claire M EricksonLindsay R Clark

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